Human papillomavirus 16 exhibits a similar integration pattern in primary squamous cell carcinoma of the penis and in its metastasis

F. Scinicariello, P. Rady, D. Saltzstein, Eduardo Orihuela, S. K. Tyring

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background. Human papillomaviruses (HPV) are among the most common causes of sexually transmitted viral infections in the United States, and HPV types 16, 18, and others have been strongly linked with the development of cervical cancer. DNA from these oncogenic HPV types also has been detected in biopsy specimens of penile intraepithelial and invasive neoplasms, indicating a causal role of these viruses in the malignant transformation of these tissue. Methods. Southern blot analysis and two-dimensional gel electrophoresis were used to investigate the presence and physical state of HPV in a patient with metastatic penile carcinoma. Results. The presence of HPV 16 DNA integrated into the host's genome was documented in a primary penile squamous cell carcinoma and its lymph node metastasis. Conclusions. The identical restriction endonuclease cleavage patterns for HPV 16 in both the primary tumor and its lymph node metastasis indicate that both tumors arose from a single clonal event. This finding provides evidence of a causal role of HPV in squamous cell carcinoma of male genitalia.

Original languageEnglish (US)
Pages (from-to)2143-2148
Number of pages6
JournalCancer
Volume70
Issue number8
DOIs
StatePublished - 1992

Fingerprint

Human papillomavirus 16
Penis
Squamous Cell Carcinoma
Neoplasm Metastasis
Lymph Nodes
Penile Neoplasms
Male Genitalia
Human papillomavirus 18
DNA
DNA Restriction Enzymes
Carcinoma in Situ
Electrophoresis, Gel, Two-Dimensional
Virus Diseases
Sexually Transmitted Diseases
Southern Blotting
Uterine Cervical Neoplasms
Neoplasms
Genome
Viruses
Carcinoma

Keywords

  • human papillomavirus 16
  • integration
  • metastasis
  • penis
  • squamous cell carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Human papillomavirus 16 exhibits a similar integration pattern in primary squamous cell carcinoma of the penis and in its metastasis. / Scinicariello, F.; Rady, P.; Saltzstein, D.; Orihuela, Eduardo; Tyring, S. K.

In: Cancer, Vol. 70, No. 8, 1992, p. 2143-2148.

Research output: Contribution to journalArticle

Scinicariello, F. ; Rady, P. ; Saltzstein, D. ; Orihuela, Eduardo ; Tyring, S. K. / Human papillomavirus 16 exhibits a similar integration pattern in primary squamous cell carcinoma of the penis and in its metastasis. In: Cancer. 1992 ; Vol. 70, No. 8. pp. 2143-2148.
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AU - Orihuela, Eduardo

AU - Tyring, S. K.

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