Human papillomaviruses (HPV) are associated with multiple myeloma

Deborah A. Payne, Stephen K. Tyring, S. Kumar, B. M. Patten, B. Ostermeyer Shoaib, T. S. Chan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Human papillomaviruses (HPV) are small DNA tumor viruses, and are associated with epithelial neoplasias. Although HPV are believed to be exclusively permissive in terminally differentiated squamous cells, we have previously identified HPV sequences in lymphoid tissues of five patients. Because this result suggested that the range of the host virus cells could include cells of lymphoid origin, we used PCR and in situ hybridization to analyze nonepithelial tissues of patients with multiple myeloma from two institutions. A statistically significant association was established between HPV and multiple myeloma (p < 0.001). This study supports the hypothesis that HPV can infect lymphoid cells.

Original languageEnglish (US)
Pages (from-to)345-349
Number of pages5
JournalInternational Journal of Oncology
Volume9
Issue number2
StatePublished - Aug 1996

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Multiple Myeloma
DNA Tumor Viruses
Lymphocytes
Lymphoid Tissue
In Situ Hybridization
Epithelial Cells
Viruses
Polymerase Chain Reaction
Neoplasms

Keywords

  • Bone marrow
  • HPV
  • Lymphocytes
  • Multiple myeloma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Payne, D. A., Tyring, S. K., Kumar, S., Patten, B. M., Shoaib, B. O., & Chan, T. S. (1996). Human papillomaviruses (HPV) are associated with multiple myeloma. International Journal of Oncology, 9(2), 345-349.

Human papillomaviruses (HPV) are associated with multiple myeloma. / Payne, Deborah A.; Tyring, Stephen K.; Kumar, S.; Patten, B. M.; Shoaib, B. Ostermeyer; Chan, T. S.

In: International Journal of Oncology, Vol. 9, No. 2, 08.1996, p. 345-349.

Research output: Contribution to journalArticle

Payne, DA, Tyring, SK, Kumar, S, Patten, BM, Shoaib, BO & Chan, TS 1996, 'Human papillomaviruses (HPV) are associated with multiple myeloma', International Journal of Oncology, vol. 9, no. 2, pp. 345-349.
Payne DA, Tyring SK, Kumar S, Patten BM, Shoaib BO, Chan TS. Human papillomaviruses (HPV) are associated with multiple myeloma. International Journal of Oncology. 1996 Aug;9(2):345-349.
Payne, Deborah A. ; Tyring, Stephen K. ; Kumar, S. ; Patten, B. M. ; Shoaib, B. Ostermeyer ; Chan, T. S. / Human papillomaviruses (HPV) are associated with multiple myeloma. In: International Journal of Oncology. 1996 ; Vol. 9, No. 2. pp. 345-349.
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