Human peripheral blood T lymphocyte proliferation after activation of the T cell receptor

Effects of unsaturated fatty acids

R. B. Zurier, R. G. Rossetti, C. M. Seiler, Michael Laposata

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Oils enriched in certain polyunsaturated fatty acids suppress joint pain and swelling in rheumatoid arthritis patients with active synovitis. Because T lymphocyte activation is important for propagation of joint tissue injury in patients with rheumatoid arthritis, we examined the effects of fatty acids added in vitro on proliferation of human T lymphocytes stimulated with monoclonal antibodies to CD3 and CD4. Unsaturated fatty acids reduced T cell proliferation in a dose dependent manner (dihomogammalinolenic acid>gammalinolenic acid>eicosapentaenoic acid>arachidonic acid). Removal of fatty acids from cultures before cell stimulation did not change the effects, but addition of fatty acids after cell stimulation failed to reduce T cell responses. The saturated palmitic acid did not influence T cell growth. These studies indicate that small changes in cellular fatty acids can have profound effects on early events in T cell signaling and on T cell function.

Original languageEnglish (US)
Pages (from-to)371-375
Number of pages5
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume60
Issue number5-6
DOIs
StatePublished - 1999
Externally publishedYes

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T-cells
T-Cell Antigen Receptor
Unsaturated Fatty Acids
Blood
Chemical activation
T-Lymphocytes
Fatty Acids
Rheumatoid Arthritis
8,11,14-Eicosatrienoic Acid
Cell signaling
Eicosapentaenoic Acid
Synovitis
Palmitic Acid
Cell proliferation
Arthralgia
Cell growth
Lymphocyte Activation
Cell culture
Arachidonic Acid
Swelling

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Human peripheral blood T lymphocyte proliferation after activation of the T cell receptor : Effects of unsaturated fatty acids. / Zurier, R. B.; Rossetti, R. G.; Seiler, C. M.; Laposata, Michael.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 60, No. 5-6, 1999, p. 371-375.

Research output: Contribution to journalArticle

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