Human placental opioid peptides: Correlation to the route of delivery

Mahmoud S. Ahmed, Laura W. Randall, Anna G. Cavinato, Dominic M. Desiderio, Genevieve Fridland, Baha Sibai

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The levels of opioid peptides in placental extracts were determined by means of a radioreceptor assay with two prototypical opioid ligands, 3H-ethyl ketocyclazocine and 3H-D-ala2-enkephalinamide. Opioid peptide levels were significantly higher in the placentas obtained by the vaginal route than in those by the abdominal route. The different peptides in the extract were detected by reverse phase high-performance liquid chromatography and a radioreceptor assay for all fractions. The presence of dynorphin-like peptides in several fractions suggests that one or more could be the “natural” ligand of the opioid receptors in the human placenta. A role for these peptides in parturition is a viable possibility.

Original languageEnglish (US)
Pages (from-to)703-706
Number of pages4
JournalAmerican journal of obstetrics and gynecology
Volume155
Issue number4
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

Keywords

  • Placental opioid peptides
  • mode of delivery

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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