Human placental opioid peptides

Correlation to the route of delivery

Mahmoud Ahmed, L. W. Randall, A. G. Cavinato, D. M. Desiderio, G. Fridland, B. Sibai

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The levels of opioid peptides in placental extracts were determined by means of a radioreceptor assay with two prototypical opioid ligands, 3H-ethylketocyclazocine and 3H-D-ala2-enkephalinamide. Opioid peptide levels were significantly higher in the placentas obtained by the vaginal route than in those by the abdominal route. The different peptides in the extract were detected by reverse phase high-performance liquid chromatography and a radioreceptor assay for all fractions. The presence of dynorphin-like peptides in several fractions suggest that one or more could be the 'natural' ligand of the opioid receptors in the human placenta. A role for these peptides in parturition is a viable possibility.

Original languageEnglish (US)
Pages (from-to)703-706
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume155
Issue number4
StatePublished - 1986
Externally publishedYes

Fingerprint

Opioid Peptides
Radioligand Assay
Placenta
Peptides
Placental Extracts
Ethylketocyclazocine
Ligands
Dynorphins
Opioid Receptors
Reverse-Phase Chromatography
Opioid Analgesics
High Pressure Liquid Chromatography
Parturition

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Ahmed, M., Randall, L. W., Cavinato, A. G., Desiderio, D. M., Fridland, G., & Sibai, B. (1986). Human placental opioid peptides: Correlation to the route of delivery. American Journal of Obstetrics and Gynecology, 155(4), 703-706.

Human placental opioid peptides : Correlation to the route of delivery. / Ahmed, Mahmoud; Randall, L. W.; Cavinato, A. G.; Desiderio, D. M.; Fridland, G.; Sibai, B.

In: American Journal of Obstetrics and Gynecology, Vol. 155, No. 4, 1986, p. 703-706.

Research output: Contribution to journalArticle

Ahmed, M, Randall, LW, Cavinato, AG, Desiderio, DM, Fridland, G & Sibai, B 1986, 'Human placental opioid peptides: Correlation to the route of delivery', American Journal of Obstetrics and Gynecology, vol. 155, no. 4, pp. 703-706.
Ahmed M, Randall LW, Cavinato AG, Desiderio DM, Fridland G, Sibai B. Human placental opioid peptides: Correlation to the route of delivery. American Journal of Obstetrics and Gynecology. 1986;155(4):703-706.
Ahmed, Mahmoud ; Randall, L. W. ; Cavinato, A. G. ; Desiderio, D. M. ; Fridland, G. ; Sibai, B. / Human placental opioid peptides : Correlation to the route of delivery. In: American Journal of Obstetrics and Gynecology. 1986 ; Vol. 155, No. 4. pp. 703-706.
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