Human rickettsioses: Host response and molecular pathogenesis

Casey Schroeder, Imran Chowdhury, Hema Narra, Jignesh Patel, Abha Sahni, Sanjeev Sahni

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Rickettsia are medically relevant obligately intracellular bacterial pathogens that cause potentially severe disease. As the causative agents of epidemic typhus and Rocky Mountain spotted fever, these neglected pathogens have had significant impacts on society with mortality rates reaching upwards of 50 %. Antibiotic therapies are often delayed, as initial diagnosis is difficult and easily confused with viral infections. This chapter will address Rickettsia and host interactions such as adhesion to and invasion of host target cells, endothelial pathogenesis, and immune response to rickettsioses. Further, the chapter will provide an overview of rickettsial genetics, metabolism, and secretion systems and their relationship to molecular pathogenesis.

Original languageEnglish (US)
Title of host publicationRickettsiales
Subtitle of host publicationBiology, Molecular Biology, Epidemiology, and Vaccine Development
PublisherSpringer International Publishing
Number of pages48
ISBN (Electronic)9783319468594
ISBN (Print)9783319468570
StatePublished - Jan 1 2016


  • Adhesion
  • Cytokines
  • Endothelial pathogenesis
  • Epidemic typhus
  • Genetics
  • Innate immunity
  • Intracellular bacteriaRickettsiaRocky mountain spotted fever
  • Secretion systems

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology


Dive into the research topics of 'Human rickettsioses: Host response and molecular pathogenesis'. Together they form a unique fingerprint.

Cite this