Human rickettsioses

Host response and molecular pathogenesis

Casey Schroeder, Imran Chowdhury, Hema Narra, Jignesh Patel, Abha Sahni, Sanjeev Sahni

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Rickettsia are medically relevant obligately intracellular bacterial pathogens that cause potentially severe disease. As the causative agents of epidemic typhus and Rocky Mountain spotted fever, these neglected pathogens have had significant impacts on society with mortality rates reaching upwards of 50 %. Antibiotic therapies are often delayed, as initial diagnosis is difficult and easily confused with viral infections. This chapter will address Rickettsia and host interactions such as adhesion to and invasion of host target cells, endothelial pathogenesis, and immune response to rickettsioses. Further, the chapter will provide an overview of rickettsial genetics, metabolism, and secretion systems and their relationship to molecular pathogenesis.

Original languageEnglish (US)
Title of host publicationRickettsiales
Subtitle of host publicationBiology, Molecular Biology, Epidemiology, and Vaccine Development
PublisherSpringer International Publishing
Pages399-446
Number of pages48
ISBN (Electronic)9783319468594
ISBN (Print)9783319468570
DOIs
StatePublished - Jan 1 2016

Fingerprint

Rickettsia
Rocky Mountain Spotted Fever
Epidemic Louse-Borne Typhus
Virus Diseases
Endothelial Cells
Anti-Bacterial Agents
Mortality
Therapeutics

Keywords

  • Adhesion
  • Cytokines
  • Endothelial pathogenesis
  • Epidemic typhus
  • Genetics
  • Innate immunity
  • Intracellular bacteriaRickettsiaRocky mountain spotted fever
  • Secretion systems

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Schroeder, C., Chowdhury, I., Narra, H., Patel, J., Sahni, A., & Sahni, S. (2016). Human rickettsioses: Host response and molecular pathogenesis. In Rickettsiales: Biology, Molecular Biology, Epidemiology, and Vaccine Development (pp. 399-446). Springer International Publishing. https://doi.org/10.1007/978-3-319-46859-4_19

Human rickettsioses : Host response and molecular pathogenesis. / Schroeder, Casey; Chowdhury, Imran; Narra, Hema; Patel, Jignesh; Sahni, Abha; Sahni, Sanjeev.

Rickettsiales: Biology, Molecular Biology, Epidemiology, and Vaccine Development. Springer International Publishing, 2016. p. 399-446.

Research output: Chapter in Book/Report/Conference proceedingChapter

Schroeder, C, Chowdhury, I, Narra, H, Patel, J, Sahni, A & Sahni, S 2016, Human rickettsioses: Host response and molecular pathogenesis. in Rickettsiales: Biology, Molecular Biology, Epidemiology, and Vaccine Development. Springer International Publishing, pp. 399-446. https://doi.org/10.1007/978-3-319-46859-4_19
Schroeder C, Chowdhury I, Narra H, Patel J, Sahni A, Sahni S. Human rickettsioses: Host response and molecular pathogenesis. In Rickettsiales: Biology, Molecular Biology, Epidemiology, and Vaccine Development. Springer International Publishing. 2016. p. 399-446 https://doi.org/10.1007/978-3-319-46859-4_19
Schroeder, Casey ; Chowdhury, Imran ; Narra, Hema ; Patel, Jignesh ; Sahni, Abha ; Sahni, Sanjeev. / Human rickettsioses : Host response and molecular pathogenesis. Rickettsiales: Biology, Molecular Biology, Epidemiology, and Vaccine Development. Springer International Publishing, 2016. pp. 399-446
@inbook{e783710ec9f1464f98852fef144973df,
title = "Human rickettsioses: Host response and molecular pathogenesis",
abstract = "Rickettsia are medically relevant obligately intracellular bacterial pathogens that cause potentially severe disease. As the causative agents of epidemic typhus and Rocky Mountain spotted fever, these neglected pathogens have had significant impacts on society with mortality rates reaching upwards of 50 {\%}. Antibiotic therapies are often delayed, as initial diagnosis is difficult and easily confused with viral infections. This chapter will address Rickettsia and host interactions such as adhesion to and invasion of host target cells, endothelial pathogenesis, and immune response to rickettsioses. Further, the chapter will provide an overview of rickettsial genetics, metabolism, and secretion systems and their relationship to molecular pathogenesis.",
keywords = "Adhesion, Cytokines, Endothelial pathogenesis, Epidemic typhus, Genetics, Innate immunity, Intracellular bacteriaRickettsiaRocky mountain spotted fever, Secretion systems",
author = "Casey Schroeder and Imran Chowdhury and Hema Narra and Jignesh Patel and Abha Sahni and Sanjeev Sahni",
year = "2016",
month = "1",
day = "1",
doi = "10.1007/978-3-319-46859-4_19",
language = "English (US)",
isbn = "9783319468570",
pages = "399--446",
booktitle = "Rickettsiales",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Human rickettsioses

T2 - Host response and molecular pathogenesis

AU - Schroeder, Casey

AU - Chowdhury, Imran

AU - Narra, Hema

AU - Patel, Jignesh

AU - Sahni, Abha

AU - Sahni, Sanjeev

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Rickettsia are medically relevant obligately intracellular bacterial pathogens that cause potentially severe disease. As the causative agents of epidemic typhus and Rocky Mountain spotted fever, these neglected pathogens have had significant impacts on society with mortality rates reaching upwards of 50 %. Antibiotic therapies are often delayed, as initial diagnosis is difficult and easily confused with viral infections. This chapter will address Rickettsia and host interactions such as adhesion to and invasion of host target cells, endothelial pathogenesis, and immune response to rickettsioses. Further, the chapter will provide an overview of rickettsial genetics, metabolism, and secretion systems and their relationship to molecular pathogenesis.

AB - Rickettsia are medically relevant obligately intracellular bacterial pathogens that cause potentially severe disease. As the causative agents of epidemic typhus and Rocky Mountain spotted fever, these neglected pathogens have had significant impacts on society with mortality rates reaching upwards of 50 %. Antibiotic therapies are often delayed, as initial diagnosis is difficult and easily confused with viral infections. This chapter will address Rickettsia and host interactions such as adhesion to and invasion of host target cells, endothelial pathogenesis, and immune response to rickettsioses. Further, the chapter will provide an overview of rickettsial genetics, metabolism, and secretion systems and their relationship to molecular pathogenesis.

KW - Adhesion

KW - Cytokines

KW - Endothelial pathogenesis

KW - Epidemic typhus

KW - Genetics

KW - Innate immunity

KW - Intracellular bacteriaRickettsiaRocky mountain spotted fever

KW - Secretion systems

UR - http://www.scopus.com/inward/record.url?scp=85023628815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85023628815&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-46859-4_19

DO - 10.1007/978-3-319-46859-4_19

M3 - Chapter

SN - 9783319468570

SP - 399

EP - 446

BT - Rickettsiales

PB - Springer International Publishing

ER -