Human rickettsioses: Host response and molecular pathogenesis

Casey Schroeder, Imran Chowdhury, Hema Narra, Jignesh Patel, Abha Sahni, Sanjeev Sahni

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Rickettsia are medically relevant obligately intracellular bacterial pathogens that cause potentially severe disease. As the causative agents of epidemic typhus and Rocky Mountain spotted fever, these neglected pathogens have had significant impacts on society with mortality rates reaching upwards of 50 %. Antibiotic therapies are often delayed, as initial diagnosis is difficult and easily confused with viral infections. This chapter will address Rickettsia and host interactions such as adhesion to and invasion of host target cells, endothelial pathogenesis, and immune response to rickettsioses. Further, the chapter will provide an overview of rickettsial genetics, metabolism, and secretion systems and their relationship to molecular pathogenesis.

Original languageEnglish (US)
Title of host publicationRickettsiales
Subtitle of host publicationBiology, Molecular Biology, Epidemiology, and Vaccine Development
PublisherSpringer International Publishing
Pages399-446
Number of pages48
ISBN (Electronic)9783319468594
ISBN (Print)9783319468570
DOIs
StatePublished - Jan 1 2016

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Keywords

  • Adhesion
  • Cytokines
  • Endothelial pathogenesis
  • Epidemic typhus
  • Genetics
  • Innate immunity
  • Intracellular bacteriaRickettsiaRocky mountain spotted fever
  • Secretion systems

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Schroeder, C., Chowdhury, I., Narra, H., Patel, J., Sahni, A., & Sahni, S. (2016). Human rickettsioses: Host response and molecular pathogenesis. In Rickettsiales: Biology, Molecular Biology, Epidemiology, and Vaccine Development (pp. 399-446). Springer International Publishing. https://doi.org/10.1007/978-3-319-46859-4_19