Human serum Cohn fraction IV (α-globin enriched) inhibits ligand binding at neurotransmitter receptors in human brain

A. C. Andorn, M. A. Pappolla, H. Fox, F. K. Klemens, P. A. Martello

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Human serum proteins are found in significant density in the neuropil in brains of demented individuals. The functional significance of these abnormally distributed proteins has been unknown. We now report that α-globulin-enriched fractions of human serum decrease the specific binding of [3H]spiroperidol at its binding sites in postmortem human frontal cortex and caudate. The substances in this serum fraction apparently exert their effect by a direct action on the binding site. Since [3H]spiroperidol labels serotoninergic and dopaminergic among other neurotransmitter receptors, these results suggest that components of human serum inhibit the binding of ligands at neurotransmitter receptors.

Original languageEnglish (US)
Pages (from-to)4572-4575
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number12
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

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