Human spinal arachnoid villi revisited

Immunohistological study and review of the literature

R. Shane Tubbs, Ake Hansasuta, William Stetler, David R. Kelly, Danitra Blevins, Rita Humphrey, Gina D. Chua, Mohammadali Mohajel Shoja, Marios Loukas, W. Jerry Oakes

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Object. Few have described the relationship between arachnoid protrusions (villi) and adjacent spinal radicular veins, and the descriptions that do exist are conflicting. Some authors have even denied the presence of spinal arachnoid villi, suggesting that they play no role in cerebrospinal fluid (CSF) absorption. Methods. To further elucidate these structures, laminectomies from C-2 inferiorly to S-2 were performed in 10 fresh human adult cadavers. Following removal of the laminae, the dural nerve sleeves were identified and the spinal nerves excised 1 cm lateral and medial to the intervertebral foramina. Samples were submitted for histological and immunohistological analysis. Results. The authors identified arachnoid villi in all specimens. The length of these structures was approximately 50 to 170 μm. Regionally, these villi were more concentrated in the lumbar region, but they were not present at every vertebral level, with observed skip zones. Occasionally, more than one villus was identified per vertebral level. The majority of villi were intimately related to an adjacent radicular vein. There was a direct relationship between the size of the adjacent radicular vein, and the presence and number of arachnoid villi. Conclusions. Findings in the present study have demonstrated that arachnoid villi exist and are morphologically associated with radicular veins. These data support the theory that CSF absorption occurs not only intracranially but also along the spinal axis. Further animal studies are necessary to prove that CSF traverses these villi and is absorbed into the spinal venous system.

Original languageEnglish (US)
Pages (from-to)328-331
Number of pages4
JournalJournal of Neurosurgery: Spine
Volume7
Issue number3
DOIs
StatePublished - Sep 1 2007
Externally publishedYes

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Arachnoid
Veins
Cerebrospinal Fluid
Lumbosacral Region
Spinal Nerves
Laminectomy
Cadaver

Keywords

  • Absorption
  • Anatomy
  • Cerebrospinal fluid
  • Spine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tubbs, R. S., Hansasuta, A., Stetler, W., Kelly, D. R., Blevins, D., Humphrey, R., ... Oakes, W. J. (2007). Human spinal arachnoid villi revisited: Immunohistological study and review of the literature. Journal of Neurosurgery: Spine, 7(3), 328-331. https://doi.org/10.3171/SPI-07/09/328

Human spinal arachnoid villi revisited : Immunohistological study and review of the literature. / Tubbs, R. Shane; Hansasuta, Ake; Stetler, William; Kelly, David R.; Blevins, Danitra; Humphrey, Rita; Chua, Gina D.; Mohajel Shoja, Mohammadali; Loukas, Marios; Oakes, W. Jerry.

In: Journal of Neurosurgery: Spine, Vol. 7, No. 3, 01.09.2007, p. 328-331.

Research output: Contribution to journalArticle

Tubbs, RS, Hansasuta, A, Stetler, W, Kelly, DR, Blevins, D, Humphrey, R, Chua, GD, Mohajel Shoja, M, Loukas, M & Oakes, WJ 2007, 'Human spinal arachnoid villi revisited: Immunohistological study and review of the literature', Journal of Neurosurgery: Spine, vol. 7, no. 3, pp. 328-331. https://doi.org/10.3171/SPI-07/09/328
Tubbs, R. Shane ; Hansasuta, Ake ; Stetler, William ; Kelly, David R. ; Blevins, Danitra ; Humphrey, Rita ; Chua, Gina D. ; Mohajel Shoja, Mohammadali ; Loukas, Marios ; Oakes, W. Jerry. / Human spinal arachnoid villi revisited : Immunohistological study and review of the literature. In: Journal of Neurosurgery: Spine. 2007 ; Vol. 7, No. 3. pp. 328-331.
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