Human umbilical vessels: Responses to agents frequently used in obstetric patients

Michael A. Belfort, George Saade, Maya Suresh, David Johnson, Yuri P. Vedernikov

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

OBJECTIVE: Our purpose was to study the effects of some drugs frequently used in pregnant women on isolated human umbilical artery and vein segments. STUDY DESIGN: Umbilical artery and vein rings from normal term pregnancies were mounted in Krebs-bicarbonate solution in organ baths for isometric tension recording. Rings were contracted with potassium chloride (60 mmol/L) or U46619 (10-8 mol/L) and then exposed to cumulative concentrations of nimodipine, nifedipine, nicardipine, phenytoin, magnesium sulfate, and hydralazine. Concentration-response curves were constructed by means of the difference in the percent relaxation between test and control vessels. Data analysis was by repeated measures analysis of variance, Newman-Keuls test, and the unpaired Student t test as appropriate. A value of p < 0.05 was considered statistically significant. RESULTS: All the agents studied were effective umbilical vasodilators, excet for hydralazine, which had minimal effect. The dihydropyridine calcium antagonists were more potent vasodilators than were the other agents studied. Nifedipine was the most potent calcium blocker and was the only dihydropyridine that relaxed the umbilical vein to a greater extent than the umbilical artery. CONCLUSION: The most commonly used drugs in preeclampsia have variable effects on the umbilical vessels.

Original languageEnglish (US)
Pages (from-to)1395-1403
Number of pages9
JournalAmerican Journal of Obstetrics and Gynecology
Volume172
Issue number5
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Umbilicus
Umbilical Veins
Umbilical Arteries
Obstetrics
Hydralazine
Nifedipine
Vasodilator Agents
Calcium
Nicardipine
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Magnesium Sulfate
Nimodipine
Potassium Chloride
Phenytoin
Bicarbonates
Pre-Eclampsia
Baths
Pharmaceutical Preparations
Pregnant Women
Analysis of Variance

Keywords

  • dihydropyridines
  • hydralazine
  • magnesium sulfate
  • phenytoin
  • Umbilical vessels

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Human umbilical vessels : Responses to agents frequently used in obstetric patients. / Belfort, Michael A.; Saade, George; Suresh, Maya; Johnson, David; Vedernikov, Yuri P.

In: American Journal of Obstetrics and Gynecology, Vol. 172, No. 5, 1995, p. 1395-1403.

Research output: Contribution to journalArticle

Belfort, Michael A. ; Saade, George ; Suresh, Maya ; Johnson, David ; Vedernikov, Yuri P. / Human umbilical vessels : Responses to agents frequently used in obstetric patients. In: American Journal of Obstetrics and Gynecology. 1995 ; Vol. 172, No. 5. pp. 1395-1403.
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