Humoral factors determining the blood pressure response to converting enzyme inhibition and calcium channel blockade

R. R. Evans, W. R. Davis, J. M. Wallace, D. J. Dipette, O. B. Holland

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Renin and catecholamine levels were determined in patients with mild to moderate hypertension before and after treatment with sustained release diltiazem or captopril and were correlated with the blood pressure response to these antihypertensives. Eight weeks of treatment with either agent led to equal decreases in both systolic and diastolic blood pressure. Pretreatment plasma renin activity (PRA) and plasma norepinephrine did not predict the blood pressure response to either agent. Diltiazem significantly increased both PRA and supine norepinephrine levels. However, in the diltiazem treated patients, there was no correlation between the change in plasma norepinephrine and the change in systolic or diastolic blood pressure. In contrast, there was a negative correlation (P<.05) between the reactive rise in PRA and the decrease in systolic blood pressure. Thus, the antihypertensive response to a calcium channel blocker may be determined, in part, by the reactive response of pressor systems.

Original languageEnglish (US)
Pages (from-to)605-610
Number of pages6
JournalAmerican Journal of Hypertension
Volume3
Issue number8 I
StatePublished - 1990

Fingerprint

Calcium Channels
Blood Pressure
Enzymes
Renin
Diltiazem
Norepinephrine
Antihypertensive Agents
Captopril
Calcium Channel Blockers
Catecholamines
Hypertension
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Evans, R. R., Davis, W. R., Wallace, J. M., Dipette, D. J., & Holland, O. B. (1990). Humoral factors determining the blood pressure response to converting enzyme inhibition and calcium channel blockade. American Journal of Hypertension, 3(8 I), 605-610.

Humoral factors determining the blood pressure response to converting enzyme inhibition and calcium channel blockade. / Evans, R. R.; Davis, W. R.; Wallace, J. M.; Dipette, D. J.; Holland, O. B.

In: American Journal of Hypertension, Vol. 3, No. 8 I, 1990, p. 605-610.

Research output: Contribution to journalArticle

Evans, RR, Davis, WR, Wallace, JM, Dipette, DJ & Holland, OB 1990, 'Humoral factors determining the blood pressure response to converting enzyme inhibition and calcium channel blockade', American Journal of Hypertension, vol. 3, no. 8 I, pp. 605-610.
Evans, R. R. ; Davis, W. R. ; Wallace, J. M. ; Dipette, D. J. ; Holland, O. B. / Humoral factors determining the blood pressure response to converting enzyme inhibition and calcium channel blockade. In: American Journal of Hypertension. 1990 ; Vol. 3, No. 8 I. pp. 605-610.
@article{96d57b12003447fd9cb2671cfe6e9850,
title = "Humoral factors determining the blood pressure response to converting enzyme inhibition and calcium channel blockade",
abstract = "Renin and catecholamine levels were determined in patients with mild to moderate hypertension before and after treatment with sustained release diltiazem or captopril and were correlated with the blood pressure response to these antihypertensives. Eight weeks of treatment with either agent led to equal decreases in both systolic and diastolic blood pressure. Pretreatment plasma renin activity (PRA) and plasma norepinephrine did not predict the blood pressure response to either agent. Diltiazem significantly increased both PRA and supine norepinephrine levels. However, in the diltiazem treated patients, there was no correlation between the change in plasma norepinephrine and the change in systolic or diastolic blood pressure. In contrast, there was a negative correlation (P<.05) between the reactive rise in PRA and the decrease in systolic blood pressure. Thus, the antihypertensive response to a calcium channel blocker may be determined, in part, by the reactive response of pressor systems.",
author = "Evans, {R. R.} and Davis, {W. R.} and Wallace, {J. M.} and Dipette, {D. J.} and Holland, {O. B.}",
year = "1990",
language = "English (US)",
volume = "3",
pages = "605--610",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "8 I",

}

TY - JOUR

T1 - Humoral factors determining the blood pressure response to converting enzyme inhibition and calcium channel blockade

AU - Evans, R. R.

AU - Davis, W. R.

AU - Wallace, J. M.

AU - Dipette, D. J.

AU - Holland, O. B.

PY - 1990

Y1 - 1990

N2 - Renin and catecholamine levels were determined in patients with mild to moderate hypertension before and after treatment with sustained release diltiazem or captopril and were correlated with the blood pressure response to these antihypertensives. Eight weeks of treatment with either agent led to equal decreases in both systolic and diastolic blood pressure. Pretreatment plasma renin activity (PRA) and plasma norepinephrine did not predict the blood pressure response to either agent. Diltiazem significantly increased both PRA and supine norepinephrine levels. However, in the diltiazem treated patients, there was no correlation between the change in plasma norepinephrine and the change in systolic or diastolic blood pressure. In contrast, there was a negative correlation (P<.05) between the reactive rise in PRA and the decrease in systolic blood pressure. Thus, the antihypertensive response to a calcium channel blocker may be determined, in part, by the reactive response of pressor systems.

AB - Renin and catecholamine levels were determined in patients with mild to moderate hypertension before and after treatment with sustained release diltiazem or captopril and were correlated with the blood pressure response to these antihypertensives. Eight weeks of treatment with either agent led to equal decreases in both systolic and diastolic blood pressure. Pretreatment plasma renin activity (PRA) and plasma norepinephrine did not predict the blood pressure response to either agent. Diltiazem significantly increased both PRA and supine norepinephrine levels. However, in the diltiazem treated patients, there was no correlation between the change in plasma norepinephrine and the change in systolic or diastolic blood pressure. In contrast, there was a negative correlation (P<.05) between the reactive rise in PRA and the decrease in systolic blood pressure. Thus, the antihypertensive response to a calcium channel blocker may be determined, in part, by the reactive response of pressor systems.

UR - http://www.scopus.com/inward/record.url?scp=0025126843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025126843&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 605

EP - 610

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 8 I

ER -