Hungry bone syndrome

Clinical and biochemical predictors of its occurrence after parathyroid surgery

Allan R. Brasier, Samuel R. Nussbaum

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

The hospital course of 218 consecutive patients with primary hyperparathyroidism admitted over a three-year period for parathyroidectomy at the Massachusetts General Hospital was reviewed to determine the incidence and identify the risk factors for the development of the hungry bone syndrome. Twenty-five patients with the hungry bone syndrome were identified (12.6 percent). Compared to patients with uncomplicated metabolic responses to parathyroid surgery, these patients were older by a mean of 10 years; they had higher preoperative serum levels of calcium, alkaline phosphatase, N-terminal parathyroid hormone, and blood urea nitrogen; and their resected parathyroid adenomata were larger. The mean duration of hospitalization averaged three days longer in the group with hungry bone disease. Stepwise multivariate analysis of preoperative variables enabled the development of a discriminant function for prediction of postoperative hypocalcemia and hypophosphatemia. Identified predictive variables were volume of resected parathyroid adenoma, blood urea nitrogen, alkaline phosphatase, and age. When validated on an independent patient population, these readily obtainable preoperative clinical and laboratory parameters will allow identification of a subgroup of patients who are at greater risk for the development of the hungry bone syndrome following parathyroid surgery.

Original languageEnglish (US)
Pages (from-to)654-660
Number of pages7
JournalThe American Journal of Medicine
Volume84
Issue number4
DOIs
StatePublished - 1988
Externally publishedYes

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Bone and Bones
Parathyroid Neoplasms
Blood Urea Nitrogen
Bone Development
Alkaline Phosphatase
Hypophosphatemia
Parathyroidectomy
Primary Hyperparathyroidism
Hypocalcemia
Bone Diseases
Parathyroid Hormone
General Hospitals
Hospitalization
Multivariate Analysis
Calcium
Incidence
Serum
Population

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Hungry bone syndrome : Clinical and biochemical predictors of its occurrence after parathyroid surgery. / Brasier, Allan R.; Nussbaum, Samuel R.

In: The American Journal of Medicine, Vol. 84, No. 4, 1988, p. 654-660.

Research output: Contribution to journalArticle

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