Huntington's disease: An immune perspective

Annapurna Nayak, Rafia Ansar, Sunil K. Verma, Domenico Marco Bonifati, Uday Kishore

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD.

Original languageEnglish (US)
Article number563784
JournalNeurology Research International
Volume2011
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

Huntington Disease
Neurodegenerative Diseases
Trinucleotide Repeat Expansion
Mutant Proteins
Nervous System
Brain
Research

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Nayak, A., Ansar, R., Verma, S. K., Bonifati, D. M., & Kishore, U. (2011). Huntington's disease: An immune perspective. Neurology Research International, 2011, [563784]. https://doi.org/10.1155/2011/563784

Huntington's disease : An immune perspective. / Nayak, Annapurna; Ansar, Rafia; Verma, Sunil K.; Bonifati, Domenico Marco; Kishore, Uday.

In: Neurology Research International, Vol. 2011, 563784, 2011.

Research output: Contribution to journalArticle

Nayak, A, Ansar, R, Verma, SK, Bonifati, DM & Kishore, U 2011, 'Huntington's disease: An immune perspective', Neurology Research International, vol. 2011, 563784. https://doi.org/10.1155/2011/563784
Nayak A, Ansar R, Verma SK, Bonifati DM, Kishore U. Huntington's disease: An immune perspective. Neurology Research International. 2011;2011. 563784. https://doi.org/10.1155/2011/563784
Nayak, Annapurna ; Ansar, Rafia ; Verma, Sunil K. ; Bonifati, Domenico Marco ; Kishore, Uday. / Huntington's disease : An immune perspective. In: Neurology Research International. 2011 ; Vol. 2011.
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