Huntington's disease: An immune perspective

Annapurna Nayak; Rafia Ansar; Sunil K. Verma; Domenico Marco Bonifati; Uday Kishore

doi:10.1155/2011/563784

Huntington's disease: An immune perspective

Annapurna Nayak, Rafia Ansar, Sunil K. Verma, Domenico Marco Bonifati, Uday Kishore

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD.

Original language	English (US)
Article number	563784
Journal	Neurology Research International
Volume	2011
DOIs	https://doi.org/10.1155/2011/563784
State	Published - 2011
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Huntington's disease: An immune perspective",

abstract = "Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD.",

author = "Annapurna Nayak and Rafia Ansar and Verma, {Sunil K.} and Bonifati, {Domenico Marco} and Uday Kishore",

year = "2011",

doi = "10.1155/2011/563784",

language = "English (US)",

volume = "2011",

journal = "Neurology Research International",

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AU - Nayak, Annapurna

AU - Ansar, Rafia

AU - Verma, Sunil K.

AU - Bonifati, Domenico Marco

AU - Kishore, Uday

PY - 2011

Y1 - 2011

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AB - Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD.

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DO - 10.1155/2011/563784

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JO - Neurology Research International

JF - Neurology Research International

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ER -

Huntington's disease: An immune perspective

Abstract

ASJC Scopus subject areas

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