Huntington's disease: An immune perspective

Annapurna Nayak, Rafia Ansar, Sunil K. Verma, Domenico Marco Bonifati, Uday Kishore

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12 Scopus citations

Abstract

Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD.

Original languageEnglish (US)
Article number563784
JournalNeurology Research International
Volume2011
DOIs
StatePublished - 2011
Externally publishedYes

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ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Nayak, A., Ansar, R., Verma, S. K., Bonifati, D. M., & Kishore, U. (2011). Huntington's disease: An immune perspective. Neurology Research International, 2011, [563784]. https://doi.org/10.1155/2011/563784