Hyalinizing clear cell carcinoma of the tonsil and its treatment

Shadi B. Hijjawi, Shaad E. Abdullah, Kareem Abdelhadi, Eduardo Eyzaguirre, Maurice Willis, Nihal E. Abdulla

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13 Scopus citations


Hyalinizing clear cell carcinoma (HCCC) is a rare neoplasm affecting mainly the minor salivary glands of the oral cavity. We describe an unusual case of HCCC involving the tonsil and its successful management. A 67-year-old Hispanic woman was discovered to have an asymptomatic right tonsillar mass on routine clinic visit that revealed HCCC on biopsy. A right radical tonsillectomy was performed and pathology confirmed HCCC with positive deep surgical margins. She declined the recommended adjuvant radiation therapy. A follow-up CT of the neck with contrast done a year later revealed a suspicious area of enhancement around the prior resection margin with regional cervical lymphadenopathy. Further workup, including biopsy, confirmed local recurrence. She was treated with definitive cisplatin-based chemoradiotherapy, achieving complete response. She remains without recurrence with more than 24 months of follow-up.

Original languageEnglish (US)
Pages (from-to)e32-e36
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Issue number2
StatePublished - Aug 2012

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging


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