Hybrid and potentially pathogenic Escherichia coli strains

Victor A. Garcia-Angulo, Mauricio J. Farfan, Alfredo Torres

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

In addition to the well-established and extensively studied categories of pathogenic E. coli, there are other groups of E. coli associated with diarrheal and/or inflammatory bowel diseases that have not been thoroughly characterized or which are considered newly emergent pathogens. This chapter focuses on three representatives of these groups of pathogenic E. coli and the current progress understanding their role in pathogenesis. Diffusely adherent E. coli (DAEC) are a collection of isolates that colonize the small bowel, considered potentially diarrheagenic, and that can cause childhood diarrhea. Adherent and invasive E. coli (AIEC) are a group of mucosa-associated bacteria with invasive properties in Crohn's disease patients and can survive and replicate extensively in macrophages. Finally, E. coli O104:H4, a hybrid Shiga toxin-producing enteroaggregative E. coli, which caused a large outbreak in Europe in 2011, displays a unique combination of virulence traits resulting in the development of hemolytic uremic syndrome in an unusually large proportion of infected patients. This chapter summarizes recent progress in understanding the pathogenesis and the clinical outcome of these types of E. coli infections.

Original languageEnglish (US)
Title of host publicationEscherichia coli: Pathotypes and Principles of Pathogenesis: Second Edition
PublisherElsevier Inc.
Pages331-359
Number of pages29
ISBN (Print)9780123970480
DOIs
StatePublished - Aug 5 2013

Fingerprint

Escherichia coli
Shiga Toxin
Escherichia coli Infections
Hemolytic-Uremic Syndrome
Inflammatory Bowel Diseases
Crohn Disease
Disease Outbreaks
Virulence
Diarrhea
Mucous Membrane
Macrophages
Bacteria

Keywords

  • Adherent invasive E. coli
  • Crohn's disease
  • Diarrhea
  • Diffusely adherent E. coli
  • E. coli O104:H4
  • Inflammatory bowel disease
  • Pathogenic E. coli

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Garcia-Angulo, V. A., Farfan, M. J., & Torres, A. (2013). Hybrid and potentially pathogenic Escherichia coli strains. In Escherichia coli: Pathotypes and Principles of Pathogenesis: Second Edition (pp. 331-359). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-397048-0.00011-5

Hybrid and potentially pathogenic Escherichia coli strains. / Garcia-Angulo, Victor A.; Farfan, Mauricio J.; Torres, Alfredo.

Escherichia coli: Pathotypes and Principles of Pathogenesis: Second Edition. Elsevier Inc., 2013. p. 331-359.

Research output: Chapter in Book/Report/Conference proceedingChapter

Garcia-Angulo, VA, Farfan, MJ & Torres, A 2013, Hybrid and potentially pathogenic Escherichia coli strains. in Escherichia coli: Pathotypes and Principles of Pathogenesis: Second Edition. Elsevier Inc., pp. 331-359. https://doi.org/10.1016/B978-0-12-397048-0.00011-5
Garcia-Angulo VA, Farfan MJ, Torres A. Hybrid and potentially pathogenic Escherichia coli strains. In Escherichia coli: Pathotypes and Principles of Pathogenesis: Second Edition. Elsevier Inc. 2013. p. 331-359 https://doi.org/10.1016/B978-0-12-397048-0.00011-5
Garcia-Angulo, Victor A. ; Farfan, Mauricio J. ; Torres, Alfredo. / Hybrid and potentially pathogenic Escherichia coli strains. Escherichia coli: Pathotypes and Principles of Pathogenesis: Second Edition. Elsevier Inc., 2013. pp. 331-359
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