Hydrogen sulfide and PKG in ischemia–reperfusion injury: sources, signaling, accelerators and brakes

Ioanna Andreadou, Efstathios K. Iliodromitis, Csaba Szabo, Andreas Papapetropoulos

    Research output: Contribution to journalArticle

    11 Scopus citations


    Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H<inf>2</inf>S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dependent protein kinase can lie both downstream and upstream of H<inf>2</inf>S. The current literature on this topic is reviewed and data from recent studies are integrated to propose a unifying model.

    Original languageEnglish (US)
    Article number52
    JournalBasic Research in Cardiology
    Issue number5
    StatePublished - Sep 1 2015



    • Cardioprotection
    • Hydrogen sulfide
    • Ischemia–reperfusion
    • Myocardial infarction
    • Nitric oxide
    • PKG

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)
    • Physiology

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