TY - JOUR
T1 - Hydrogen sulfide and PKG in ischemia–reperfusion injury
T2 - sources, signaling, accelerators and brakes
AU - Andreadou, Ioanna
AU - Iliodromitis, Efstathios K.
AU - Szabo, Csaba
AU - Papapetropoulos, Andreas
N1 - Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dependent protein kinase can lie both downstream and upstream of H2S. The current literature on this topic is reviewed and data from recent studies are integrated to propose a unifying model.
AB - Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dependent protein kinase can lie both downstream and upstream of H2S. The current literature on this topic is reviewed and data from recent studies are integrated to propose a unifying model.
KW - Cardioprotection
KW - Hydrogen sulfide
KW - Ischemia–reperfusion
KW - Myocardial infarction
KW - Nitric oxide
KW - PKG
UR - http://www.scopus.com/inward/record.url?scp=84941616201&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941616201&partnerID=8YFLogxK
U2 - 10.1007/s00395-015-0510-9
DO - 10.1007/s00395-015-0510-9
M3 - Editorial
C2 - 26318600
AN - SCOPUS:84941616201
SN - 0300-8428
VL - 110
JO - Basic Research in Cardiology
JF - Basic Research in Cardiology
IS - 5
M1 - 52
ER -