Hydrogen sulfide and PKG in ischemia–reperfusion injury: sources, signaling, accelerators and brakes

Ioanna Andreadou, Efstathios K. Iliodromitis, Csaba Szabo, Andreas Papapetropoulos

Research output: Contribution to journalEditorial

12 Scopus citations

Abstract

Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dependent protein kinase can lie both downstream and upstream of H2S. The current literature on this topic is reviewed and data from recent studies are integrated to propose a unifying model.

Original languageEnglish (US)
Article number52
JournalBasic Research in Cardiology
Volume110
Issue number5
DOIs
StatePublished - Sep 1 2015

Keywords

  • Cardioprotection
  • Hydrogen sulfide
  • Ischemia–reperfusion
  • Myocardial infarction
  • Nitric oxide
  • PKG

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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