Hydrogen sulfide and PKG in ischemia–reperfusion injury: sources, signaling, accelerators and brakes

Ioanna Andreadou; Efstathios K. Iliodromitis; Csaba Szabo; Andreas Papapetropoulos

doi:10.1007/s00395-015-0510-9

Hydrogen sulfide and PKG in ischemia–reperfusion injury: sources, signaling, accelerators and brakes

Ioanna Andreadou
, Efstathios K. Iliodromitis
, Csaba Szabo
, Andreas Papapetropoulos

Surgery

Research output: Contribution to journal › Editorial › peer-review

20 Scopus citations

Abstract

Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H₂S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dependent protein kinase can lie both downstream and upstream of H₂S. The current literature on this topic is reviewed and data from recent studies are integrated to propose a unifying model.

Original language	English (US)
Article number	52
Journal	Basic Research in Cardiology
Volume	110
Issue number	5
DOIs	https://doi.org/10.1007/s00395-015-0510-9
State	Published - Sep 1 2015

Keywords

Cardioprotection
Hydrogen sulfide
Ischemia–reperfusion
Myocardial infarction
Nitric oxide
PKG

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1007/s00395-015-0510-9

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title = "Hydrogen sulfide and PKG in ischemia–reperfusion injury: sources, signaling, accelerators and brakes",

abstract = "Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dependent protein kinase can lie both downstream and upstream of H2S. The current literature on this topic is reviewed and data from recent studies are integrated to propose a unifying model.",

keywords = "Cardioprotection, Hydrogen sulfide, Ischemia–reperfusion, Myocardial infarction, Nitric oxide, PKG",

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T1 - Hydrogen sulfide and PKG in ischemia–reperfusion injury

T2 - sources, signaling, accelerators and brakes

AU - Andreadou, Ioanna

AU - Iliodromitis, Efstathios K.

AU - Szabo, Csaba

AU - Papapetropoulos, Andreas

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dependent protein kinase can lie both downstream and upstream of H2S. The current literature on this topic is reviewed and data from recent studies are integrated to propose a unifying model.

AB - Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dependent protein kinase can lie both downstream and upstream of H2S. The current literature on this topic is reviewed and data from recent studies are integrated to propose a unifying model.

KW - Cardioprotection

KW - Hydrogen sulfide

KW - Ischemia–reperfusion

KW - Myocardial infarction

KW - Nitric oxide

KW - PKG

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M3 - Editorial

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AN - SCOPUS:84941616201

SN - 0300-8428

VL - 110

JO - Basic Research in Cardiology

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IS - 5

M1 - 52

ER -

Hydrogen sulfide and PKG in ischemia–reperfusion injury: sources, signaling, accelerators and brakes

Abstract

Keywords

ASJC Scopus subject areas

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