Hydrogen sulfide and the metabolic syndrome

Kaushik M. Desai, Tuanjie Chang, Ashley Untereiner, Lingyun Wu

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


The metabolic syndrome is a group of abnormalities including obesity, high blood pressure, hyperinsulinemia, high blood glucose levels and hyperlipidemia that together greatly increase the risk of developing cardiovascular disease and Type 2 diabetes. Hydrogen sulfide (H 2S) is a vasodilatory gasotransmitter mediator in the cardiovascular system, proposed as an endothelium-derived relaxing factor. A lack of H 2S and its synthesizing enzyme, cystathionine -lyase, in the vasculature causes hypertension, whereas an increase in the pancreas reduces insulin secretion. Thus, research is making inroads to determine whether H 2S is involved in the pathogenesis of the metabolic syndrome. Several laboratories are synthesizing and testing clinically used drugs that release H 2S. Some of these compounds are being tested for effectiveness in the metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)63-73
Number of pages11
JournalExpert Review of Clinical Pharmacology
Issue number1
StatePublished - Jan 2011
Externally publishedYes


  • diabetes
  • hydrogen sulfide
  • hypertension
  • metabolic syndrome
  • obesity

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • Pharmacology (medical)


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