Hydrogen sulfide and the metabolic syndrome

Kaushik M. Desai, Tuanjie Chang, Ashley Untereiner, Lingyun Wu

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

The metabolic syndrome is a group of abnormalities including obesity, high blood pressure, hyperinsulinemia, high blood glucose levels and hyperlipidemia that together greatly increase the risk of developing cardiovascular disease and Type 2 diabetes. Hydrogen sulfide (H 2S) is a vasodilatory gasotransmitter mediator in the cardiovascular system, proposed as an endothelium-derived relaxing factor. A lack of H 2S and its synthesizing enzyme, cystathionine -lyase, in the vasculature causes hypertension, whereas an increase in the pancreas reduces insulin secretion. Thus, research is making inroads to determine whether H 2S is involved in the pathogenesis of the metabolic syndrome. Several laboratories are synthesizing and testing clinically used drugs that release H 2S. Some of these compounds are being tested for effectiveness in the metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)63-73
Number of pages11
JournalExpert Review of Clinical Pharmacology
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2011

Keywords

  • diabetes
  • hydrogen sulfide
  • hypertension
  • metabolic syndrome
  • obesity

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Hydrogen sulfide and the metabolic syndrome'. Together they form a unique fingerprint.

  • Cite this