Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice

Michela Campolo, Emanuela Esposito, Akbar Ahmad, Rosanna Di Paola, Irene Paterniti, Marika Cordaro, Giuseppe Bruschetta, John L. Wallace, Salvatore Cuzzocrea

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Background: Traumatic brain injury (TBI) induces secondary injury mechanisms, including dynamic interplay between ischemic, inflammatory and cytotoxic processes. We recently reported that administration of ATB-346 (2-(6-methoxynapthalen- 2-yl)-propionic acid 4-thiocarbamoyl-phenyl ester), a hydrogen sulfide-releasing cyclooxygenase inhibitor, showed marked beneficial effects in an animal model of spinal cord injury, significantly enhancing recovery of motor function and reducing the secondary inflammation and tissue injury. Methods: Here we evaluated the neuroprotective potential of ATB-346, a hydrogen sulfide-releasing derivative of naproxen, using the controlled cortical impact (CCI) injury model in mice, one of the most common models of TBI. Moreover, the aim of the present study was to carefully investigate molecular pathways and subtypes of glial cells involved in the protective effect of ATB-346 on inflammatory reaction associated with an experimental model of TBI. In these studies, TBI was induced in mice by CCI and mice were orally administered ATB-346, naproxen (both at 30 μmol/kg) or vehicle (dimethylsulfoxide:1% carboxymethylcellulose [5:95] suspension) one and six hours after brain trauma and once daily for 10 days. Results: Results revealed that ATB-346 attenuated TBI-induced brain edema, suppressed TBI-induced neural cell death and improved neurological function. ATB-346 also significantly reduced the severity of inflammation and restored neurotrophic factors that characterized the secondary events of TBI. Conclusions: These data demonstrate that ATB-346 can be efficacious in a TBI animal model by reducing the secondary inflammation and tissue injury. Therefore, ATB-346 could represent an interesting approach for the management of secondary damage following CNS diseases, counteracting behavioral changes and inflammatory process.

Original languageEnglish (US)
Article number196
JournalJournal of neuroinflammation
Volume11
Issue number1
DOIs
StatePublished - Dec 4 2014

Keywords

  • Astrogliosis
  • Brain trauma
  • Hydrogen sulfide
  • Infarct area
  • Infarct volume
  • Inflammation
  • Motor recovery
  • Neuroprotection
  • Neurotrophic factor
  • Nitrosative stress

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Neurology
  • Cellular and Molecular Neuroscience

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    Campolo, M., Esposito, E., Ahmad, A., Di Paola, R., Paterniti, I., Cordaro, M., Bruschetta, G., Wallace, J. L., & Cuzzocrea, S. (2014). Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice. Journal of neuroinflammation, 11(1), [196]. https://doi.org/10.1186/s12974-014-0196-1