Hydrogen sulphide and its therapeutic potential

Csaba Szabõ

    Research output: Contribution to journalReview article

    1236 Scopus citations

    Abstract

    Hydrogen sulphide (H2S) is increasingly being recognized as an important signalling molecule in the cardiovascular and nervous systems. The production of H2S from L-cysteine is catalysed primarily by two enzymes, cystathionine γ-lyase and cystathionine β-synthase. Evidence is accumulating to demonstrate that inhibitors of H2S production or therapeutic H2S donor compounds exert significant effects in various animal models of inflammation, reperfusion injury and circulatory shock. H2S can also induce a reversible state of hypothermia and suspended-animation-like state in rodents. This article overviews the physiology and biochemistry of H2S, summarizes the effects of H2S inhibitors or H2S donors in animal models of disease and outlines the potential options for the therapeutic exploitation of H2S.

    Original languageEnglish (US)
    Pages (from-to)917-935
    Number of pages19
    JournalNature Reviews Drug Discovery
    Volume6
    Issue number11
    DOIs
    StatePublished - Nov 1 2007

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    ASJC Scopus subject areas

    • Pharmacology
    • Drug Discovery

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