Hydrolysis of inositol lipids: an early signal of human cytomegalovirus infection

T. Valyi-Nagy, Z. Bandi, I. Boldogh, T. Albrecht

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The production of inositol 1,4,5-triphosphate (IP 3) and 1,2-diacylglycerol (DG) as an early cellular response to human cytomegalovirus (HCMV) infection was investigated in human embryo lung (LU) cells. The results obtained show transient 85 and 30% increases in IP3 and DG, respectively, 20 min post-exposure to HCMV. Following heat inactivation or serum neutralization of HCMV stock or in the presence of papaverine we failed to detect increased levels of IP3 and DG relative to mock-infected LU cultures.

Original languageEnglish (US)
Pages (from-to)199-207
Number of pages9
JournalArchives of virology
Volume101
Issue number3-4
DOIs
StatePublished - Sep 1 1988

ASJC Scopus subject areas

  • Virology

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