Hydrolysis of inositol lipids: an early signal of human cytomegalovirus infection

T. Valyi-Nagy; Z. Bandi; I. Boldogh; T. Albrecht

doi:10.1007/BF01311001

Hydrolysis of inositol lipids: an early signal of human cytomegalovirus infection

T. Valyi-Nagy, Z. Bandi, I. Boldogh, T. Albrecht

Microbiology And Immunology

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34 Scopus citations

Abstract

The production of inositol 1,4,5-triphosphate (IP 3) and 1,2-diacylglycerol (DG) as an early cellular response to human cytomegalovirus (HCMV) infection was investigated in human embryo lung (LU) cells. The results obtained show transient 85 and 30% increases in IP₃ and DG, respectively, 20 min post-exposure to HCMV. Following heat inactivation or serum neutralization of HCMV stock or in the presence of papaverine we failed to detect increased levels of IP₃ and DG relative to mock-infected LU cultures.

Original language	English (US)
Pages (from-to)	199-207
Number of pages	9
Journal	Archives of virology
Volume	101
Issue number	3-4
DOIs	https://doi.org/10.1007/BF01311001
State	Published - Sep 1988

ASJC Scopus subject areas

Virology

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title = "Hydrolysis of inositol lipids: an early signal of human cytomegalovirus infection",

abstract = "The production of inositol 1,4,5-triphosphate (IP 3) and 1,2-diacylglycerol (DG) as an early cellular response to human cytomegalovirus (HCMV) infection was investigated in human embryo lung (LU) cells. The results obtained show transient 85 and 30% increases in IP3 and DG, respectively, 20 min post-exposure to HCMV. Following heat inactivation or serum neutralization of HCMV stock or in the presence of papaverine we failed to detect increased levels of IP3 and DG relative to mock-infected LU cultures.",

author = "T. Valyi-Nagy and Z. Bandi and I. Boldogh and T. Albrecht",

year = "1988",

month = sep,

doi = "10.1007/BF01311001",

language = "English (US)",

volume = "101",

pages = "199--207",

journal = "Archives of virology",

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T1 - Hydrolysis of inositol lipids

T2 - an early signal of human cytomegalovirus infection

AU - Valyi-Nagy, T.

AU - Bandi, Z.

AU - Boldogh, I.

AU - Albrecht, T.

PY - 1988/9

Y1 - 1988/9

N2 - The production of inositol 1,4,5-triphosphate (IP 3) and 1,2-diacylglycerol (DG) as an early cellular response to human cytomegalovirus (HCMV) infection was investigated in human embryo lung (LU) cells. The results obtained show transient 85 and 30% increases in IP3 and DG, respectively, 20 min post-exposure to HCMV. Following heat inactivation or serum neutralization of HCMV stock or in the presence of papaverine we failed to detect increased levels of IP3 and DG relative to mock-infected LU cultures.

AB - The production of inositol 1,4,5-triphosphate (IP 3) and 1,2-diacylglycerol (DG) as an early cellular response to human cytomegalovirus (HCMV) infection was investigated in human embryo lung (LU) cells. The results obtained show transient 85 and 30% increases in IP3 and DG, respectively, 20 min post-exposure to HCMV. Following heat inactivation or serum neutralization of HCMV stock or in the presence of papaverine we failed to detect increased levels of IP3 and DG relative to mock-infected LU cultures.

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Hydrolysis of inositol lipids: an early signal of human cytomegalovirus infection

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