Hydroxylation of prostaglandins A₁ and E₁ by liver microsomal monooxygenase. Characteristics of the enzyme system in the guinea pig

Medicine & Life Sciences

• prostaglandin A1 91%
• Aryl Hydrocarbon Hydroxylases 81%
• prostaglandin B1 70%
• Alprostadil 65%
• Hydroxylation 63%
• Guinea Pigs 48%
• hydroxide ion 31%
• Enzymes 30%
• NADP 29%
• Liver 28%
• NAD 28%
• Esters 18%
• Prostaglandins 17%
• High Pressure Liquid Chromatography 15%
• Methyl Ethers 14%
• Proadifen 13%
• Metyrapone 12%
• NADPH-Ferrihemoprotein Reductase 12%
• Niacinamide 11%
• Gas Chromatography-Mass Spectrometry 10%
• Liver Microsomes 10%
• Gas Chromatography 10%
• Mixed Function Oxygenases 10%
• Cytochromes c 9%
• Carbon Monoxide 9%
• Acids 6%
• Kinetics 6%
• Antibodies 5%
• Proteins 3%

Chemical Compounds

• Prostaglandin A1 100%
• Prostaglandin E1 82%
• Prostaglandin 21%
• Retention Time 16%
• Metyrapone 14%
• High-Pressure Liquid Chromatography 14%
• Metabolite 13%
• Nicotinamide 9%
• UV Absorption 9%
• Methyl Ester 8%
• Cytochrome 8%
• Carbon Monoxide 7%
• Fragmentation 7%
• Gas Chromatography 7%
• Gas Chromatography Mass Spectrometry (GCMS) 6%
• Ester 5%
• Protein 3%
• Acid 3%