Hyperbilirubinämie und transkutane Bilirubinbestimmung

Translated title of the contribution: Hyperbilirubinemia and transcutaneous bilirubinometry

Samar N. El-Beshbishi, Karen E. Shattuck, Amin A. Mohammad, John R. Petersen

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Neonatal jaundice or hyperbilirubinemia is a common occurrence in newborns. Although most cases of neonatal jaundice have a benign course, severe hyperbilirubinemia can lead to kernicterus, which is preventable if the hyperbilirubinemia is identified early and treated appropriately. Content: This review discusses neonatal jaundice and the use of transcutaneous bilirubin (TcB) measurements for identification of neonates at risk of severe hyperbilirubinemia. Such a practice requires appropriate serial testing and result interpretation according to risk level from a nomogram that provides bilirubin concentrations specific for the age of the neonate in hours. In this context, we have evaluated the potential impact on clinical outcome and limitations of TcB methods in current use. Summary: TcB measurement is a viable option in screening neonates to determine if they are at risk for clinically significant hyperbilirubinemia. Total serum bilirubin should be measured by a clinical laboratory if a newborn is shown to be at higher risk for clinically significant hyperbilirubinemia. In addition, external quality assessment to identify biases and operator training issues should be part of any TcB monitoring program.

Translated title of the contributionHyperbilirubinemia and transcutaneous bilirubinometry
Original languageGerman
Pages (from-to)29-37
Number of pages9
JournalLaboratoriumsMedizin
Volume34
Issue number1
DOIs
StatePublished - Feb 1 2010

Keywords

  • Bilirubin
  • Icterus neonatorum
  • Kernicterus
  • Neonates
  • Transcutaneous bilirubinometry

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Medical Laboratory Technology
  • Biochemistry, medical

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