Hypercarbia depresses cerebral oxygen consumption during cardiopulmonary bypass

Donald S. Prough, Anne T. Rogers, David A. Stump, Stephen A. Mills, Glenn P. Gravlee, Carol Taylor

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

No human studies have systematically examined the relations among Paco2, cerebral blood flow, and the cerebral metabolic rate for oxygen during hypothermic cardiopulmonary bypass. We varied Paco2 during hypothermic (26-28° C) cardiopulmonary bypass and estimated the cerebral metabolic rate for oxygen by multiplying cerebral blood flow (measured using xenon-133 clearance) by the cerebral arteriovenous difference in oxygen contents. Patients were randomly assigned to either of two methods of managing Paco2 (uncorrected for body temperature). In group 1 (Paco2 32-48 mm Hg, n = 13) the mean±SD cerebral metabolic rate for oxygen was 0.40±0.11 ml O2×l00 g−1×min−1 at a mean±SD Paco2 of 36±2.0 mm Hg and 0.40±0.14 ml O2×l00 g−1×min−1 at a mean±SD Paco2 of 45±2 mm Hg. In group 2 (Paco249-72 mm Hg, n = 12) the mean±SD cerebral metabolic rate for oxygen was 0.31 ±0.09 ml O2×l00 g−1×min−1 at a mean±SD Paco2 of 55±3 mm Hg and 0.21±0.07 ml O2×l00 g−1×min−1 at a mean±SD Paco2 of 68±2 mm Hg. Group 2 values differed significantly from those in Group 1 (p<0.05). In both groups, cerebral blood flow increased as Paco2 increased. During cardiopulmonary bypass, increasing Paco2 increases cerebral blood flow and decreases the cerebral metabolic rate for oxygen.

Original languageEnglish (US)
Pages (from-to)1162-1166
Number of pages5
JournalStroke
Volume21
Issue number8
DOIs
StatePublished - Aug 1990

    Fingerprint

Keywords

  • Cardiopulmonary bypass
  • Cerebral blood flow
  • Hypercapnia
  • Oxygen consumption

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Prough, D. S., Rogers, A. T., Stump, D. A., Mills, S. A., Gravlee, G. P., & Taylor, C. (1990). Hypercarbia depresses cerebral oxygen consumption during cardiopulmonary bypass. Stroke, 21(8), 1162-1166. https://doi.org/10.1161/01.STR.21.8.1162