TY - JOUR
T1 - Hypercoagulability test strategies in the protein C and protein S pathway
AU - Van Cott, Elizabeth M.
AU - Soderberg, Britt L.
AU - Laposata, Michael
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2002
Y1 - 2002
N2 - The protein C-protein S pathway is critical in controlling normal clot formation to provide homeostasis between thrombosis and hemorrhage. Abnormalities have been described in which the pathway is altered because factor V cannot be degraded by activated protein C, producing activated protein C resistance. It has been known for nearly two decades that deficiencies in protein C and protein S can result in impaired inhibition of clot formation resulting in increased risk for thrombosis. This article describes the testing strategies associated with the diagnosis of activated protein C resistance, protein C deficiency, and protein S deficiency.
AB - The protein C-protein S pathway is critical in controlling normal clot formation to provide homeostasis between thrombosis and hemorrhage. Abnormalities have been described in which the pathway is altered because factor V cannot be degraded by activated protein C, producing activated protein C resistance. It has been known for nearly two decades that deficiencies in protein C and protein S can result in impaired inhibition of clot formation resulting in increased risk for thrombosis. This article describes the testing strategies associated with the diagnosis of activated protein C resistance, protein C deficiency, and protein S deficiency.
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U2 - 10.1016/S0272-2712(01)00011-7
DO - 10.1016/S0272-2712(01)00011-7
M3 - Review article
C2 - 12134467
AN - SCOPUS:0035990288
SN - 0272-2712
VL - 22
SP - 391
EP - 403
JO - Clinics in Laboratory Medicine
JF - Clinics in Laboratory Medicine
IS - 2
ER -