Hypercoagulability test strategies in the protein C and protein S pathway

Elizabeth M. Van Cott, Britt L. Soderberg, Michael Laposata

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


The protein C-protein S pathway is critical in controlling normal clot formation to provide homeostasis between thrombosis and hemorrhage. Abnormalities have been described in which the pathway is altered because factor V cannot be degraded by activated protein C, producing activated protein C resistance. It has been known for nearly two decades that deficiencies in protein C and protein S can result in impaired inhibition of clot formation resulting in increased risk for thrombosis. This article describes the testing strategies associated with the diagnosis of activated protein C resistance, protein C deficiency, and protein S deficiency.

Original languageEnglish (US)
Pages (from-to)391-403
Number of pages13
JournalClinics in Laboratory Medicine
Issue number2
StatePublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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