Hypercoagulability test strategies in the protein C and protein S pathway

Elizabeth M. Van Cott, Britt L. Soderberg, Michael Laposata

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The protein C-protein S pathway is critical in controlling normal clot formation to provide homeostasis between thrombosis and hemorrhage. Abnormalities have been described in which the pathway is altered because factor V cannot be degraded by activated protein C, producing activated protein C resistance. It has been known for nearly two decades that deficiencies in protein C and protein S can result in impaired inhibition of clot formation resulting in increased risk for thrombosis. This article describes the testing strategies associated with the diagnosis of activated protein C resistance, protein C deficiency, and protein S deficiency.

Original languageEnglish (US)
Pages (from-to)391-403
Number of pages13
JournalClinics in Laboratory Medicine
Volume22
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Protein C Deficiency
Activated Protein C Resistance
Thrombophilia
Protein S
Protein C
Thrombosis
Protein S Deficiency
Critical Pathways
Factor V
Homeostasis
Hemorrhage
Testing

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hypercoagulability test strategies in the protein C and protein S pathway. / Van Cott, Elizabeth M.; Soderberg, Britt L.; Laposata, Michael.

In: Clinics in Laboratory Medicine, Vol. 22, No. 2, 2002, p. 391-403.

Research output: Contribution to journalArticle

Van Cott, Elizabeth M. ; Soderberg, Britt L. ; Laposata, Michael. / Hypercoagulability test strategies in the protein C and protein S pathway. In: Clinics in Laboratory Medicine. 2002 ; Vol. 22, No. 2. pp. 391-403.
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