Hyperglycemia in extremely low birth weight infants in a predominantly Hispanic population and related morbidities

C. L. Blanco, Jacques Baillargeon, R. L. Morrison, A. K. Gong

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Objective: This study describes the incidence, correlates and subsequent morbidities of hyperglycemia, a highly prevalent condition in extremely low birth weight (ELBW) infants. Study design: A retrospective chart review of 169 infants with birth weight (BW)<1000g was conducted. Hyperglycemia was defined as plasma glucose level ≥150mg/dl during the first 2 weeks of life. Data were analyzed by logistic regression, multivariate analysis and Fisher exact test. Results: Overall, 88% of the study sample developed hyperglycemia in the first 2 weeks of life. Both gestational age (GA) (odds ratio (OR) 0.11, 95% confidence interval (CI)=0.01-0.89) and chorioamnionitis (OR 0.10, 95% CI=0.01-0.64) were inversely associated with hyperglycemia, whereas BW, sepsis and postnatal steroid exposure were not. After adjusting for GA, BW and postnatal steroids, hyperglycemia was associated with a statistically significant increase in retinopathy of prematurity (ROP) (OR 4.6, 95% CI 1.12-18.9). No association was found with bronchopulmonary dysplasia, intraventricular hemorrhage, death or prolonged hospital stay. Conclusion: Lower GA was identified as the main factor associated with hyperglycemia in ELBW infants during the first 2 weeks of life. Hyperglycemia was associated with an increased incidence of ROP; further studies need to determine if this association is causal.

Original languageEnglish (US)
Pages (from-to)737-741
Number of pages5
JournalJournal of Perinatology
Volume26
Issue number12
DOIs
StatePublished - Dec 2006

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Extremely Low Birth Weight Infant
Hispanic Americans
Hyperglycemia
Morbidity
Population
Birth Weight
Gestational Age
Retinopathy of Prematurity
Odds Ratio
Confidence Intervals
Steroids
Chorioamnionitis
Bronchopulmonary Dysplasia
Length of Stay
Sepsis
Cohort Studies
Multivariate Analysis
Logistic Models
Regression Analysis
Hemorrhage

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Hyperglycemia in extremely low birth weight infants in a predominantly Hispanic population and related morbidities. / Blanco, C. L.; Baillargeon, Jacques; Morrison, R. L.; Gong, A. K.

In: Journal of Perinatology, Vol. 26, No. 12, 12.2006, p. 737-741.

Research output: Contribution to journalArticle

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