Hyperglycemic pseudohypoxia and diabetic complications

Joseph R. Williamson, Katherine Chang, Myrto Frangos, Khalid S. Hasan, Yasuo Ido, Takahiko Kawamura, Jens R. Nyengaard, Maria Van Den Enden, Charles Kilo, Ronald Tilton

Research output: Contribution to journalArticle

965 Citations (Scopus)

Abstract

Vasodilation and increased blood flow are characteristic early vascular responses to acute hyperglycemia and tissue hypoxia. In hypoxic tissues these vascular changes are linked to metabolic imbalances associated with impaired oxidation of NADH to NAD+ and the resulting increased ratio of NADH/NAD+. In hyperglycemic tissues these vascular changes also are linked to an increased ratio of NADH/NAD+, in this case because of an increased rate of reduction of NAD+ to NADH. Several lines of evidence support the likelihood that the increased cytosolic ratio of free NADH/NAD+ caused by hyperglycemia, referred to as pseudohypoxia because tissue partial pressure oxygen is normal, is a characteristic feature of poorly controlled diabetes that mimics the effects of true hypoxia on vascular and neural function and plays an important role in the pathogenesis of diabetic complications. These effects of hypoxia and hyperglycemia-induced pseudohypoxia on vascular and neural function are mediated by a branching cascade of imbalances in lipid metabolism, increased production of superoxide anion, and possibly increased nitric oxide formation.

Original languageEnglish (US)
Pages (from-to)801-813
Number of pages13
JournalDiabetes
Volume42
Issue number6
StatePublished - Jun 1993
Externally publishedYes

Fingerprint

Diabetes Complications
NAD
Blood Vessels
Hyperglycemia
Partial Pressure
Lipid Metabolism
Vasodilation
Superoxides
Nitric Oxide
Oxygen

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Williamson, J. R., Chang, K., Frangos, M., Hasan, K. S., Ido, Y., Kawamura, T., ... Tilton, R. (1993). Hyperglycemic pseudohypoxia and diabetic complications. Diabetes, 42(6), 801-813.

Hyperglycemic pseudohypoxia and diabetic complications. / Williamson, Joseph R.; Chang, Katherine; Frangos, Myrto; Hasan, Khalid S.; Ido, Yasuo; Kawamura, Takahiko; Nyengaard, Jens R.; Van Den Enden, Maria; Kilo, Charles; Tilton, Ronald.

In: Diabetes, Vol. 42, No. 6, 06.1993, p. 801-813.

Research output: Contribution to journalArticle

Williamson, JR, Chang, K, Frangos, M, Hasan, KS, Ido, Y, Kawamura, T, Nyengaard, JR, Van Den Enden, M, Kilo, C & Tilton, R 1993, 'Hyperglycemic pseudohypoxia and diabetic complications', Diabetes, vol. 42, no. 6, pp. 801-813.
Williamson JR, Chang K, Frangos M, Hasan KS, Ido Y, Kawamura T et al. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes. 1993 Jun;42(6):801-813.
Williamson, Joseph R. ; Chang, Katherine ; Frangos, Myrto ; Hasan, Khalid S. ; Ido, Yasuo ; Kawamura, Takahiko ; Nyengaard, Jens R. ; Van Den Enden, Maria ; Kilo, Charles ; Tilton, Ronald. / Hyperglycemic pseudohypoxia and diabetic complications. In: Diabetes. 1993 ; Vol. 42, No. 6. pp. 801-813.
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AU - Kawamura, Takahiko

AU - Nyengaard, Jens R.

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