Hyperinsulinemia and hyperandrogenemia

In vivo androgen response to insulin infusion

C. A. Stuart, M. J. Prince, E. J. Peters, Walter Meyer

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The plasma androgen responses to multiple-dose insulin infusions were determined in six normal females, four normal males, five obese females, and in three females with severe insulin resistance, hirsutism, and acanthosis nigricans. During the insulin infusions, the plasma glucose concentrations were maintained at 85 ± 1 mg/dL by variable infusions of dextrose. Plasma androstenedione was augmented by 27-39% at physiologic insulin concentrations in the normal subjects and the obese group, and by 25% at hyperinsulinemic levels in the insulin-resistant group with acanthosis nigricans. The increased androstenedione concentrations achieved in the normal females and obese females were similar to the hyperandrogenemic levels seen in the acanthotic subjects in the basal state. Plasma cortisol also increased in all groups from 19% in normal females to 135% in obese females during the insulin infusions, but these changes did not reach statistical significance. These studies suggest that hyperinsulinemia may play a pathogenic role in the hyperandrogenemia of polycystic ovarian disease.

Original languageEnglish (US)
Pages (from-to)921-925
Number of pages5
JournalObstetrics and Gynecology
Volume69
Issue number6
StatePublished - 1987

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Hyperinsulinism
Androgens
Insulin
Acanthosis Nigricans
Androstenedione
Ovarian Diseases
Glucose
Hirsutism
Insulin Resistance
Hydrocortisone

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Stuart, C. A., Prince, M. J., Peters, E. J., & Meyer, W. (1987). Hyperinsulinemia and hyperandrogenemia: In vivo androgen response to insulin infusion. Obstetrics and Gynecology, 69(6), 921-925.

Hyperinsulinemia and hyperandrogenemia : In vivo androgen response to insulin infusion. / Stuart, C. A.; Prince, M. J.; Peters, E. J.; Meyer, Walter.

In: Obstetrics and Gynecology, Vol. 69, No. 6, 1987, p. 921-925.

Research output: Contribution to journalArticle

Stuart, CA, Prince, MJ, Peters, EJ & Meyer, W 1987, 'Hyperinsulinemia and hyperandrogenemia: In vivo androgen response to insulin infusion', Obstetrics and Gynecology, vol. 69, no. 6, pp. 921-925.
Stuart, C. A. ; Prince, M. J. ; Peters, E. J. ; Meyer, Walter. / Hyperinsulinemia and hyperandrogenemia : In vivo androgen response to insulin infusion. In: Obstetrics and Gynecology. 1987 ; Vol. 69, No. 6. pp. 921-925.
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