Hyperthermic potentiation of chromosome aberrations by anticancer antibiotics

B. K. Vig, Michael Cornforth, S. A F Farook

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In view of the success of hyperthermia as a modality in cancer treatment, we have studied its effect on chromosomes in combination with anticancer antibiotics. Three classes of chemicals, one with a non-delayed type of effect (adriamycin), one with a delayed type of effect (mitomycin C), and one with a truely radio-mimetic effect (bleomycin) were selected for study on human lymphocytes and Chinese hamster K-1 cells. Propane sultone was also included because its effect on plants is suppressed by hyperthermia. The data show increased potential of these chemicals to induce chromosome aberrations when applied at temperatures higher than 37°C, irrespective of the phase of cell cycle. The potentiation may be due to true synergism (bleomycin) or facilitation of entry of larger quantities of the drug (adriamycin). No potentiating effect was observed on the induction of sister chromatid exchanges (SCEs).

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalCytogenetics and Cell Genetics
Volume33
Issue number1-2
StatePublished - 1982
Externally publishedYes

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Bleomycin
Chromosome Aberrations
Doxorubicin
Fever
Anti-Bacterial Agents
Sister Chromatid Exchange
Mitomycin
Cricetulus
Radio
Cell Cycle
Chromosomes
Lymphocytes
Temperature
Pharmaceutical Preparations
Neoplasms
1,3-propane sultone

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

Cite this

Hyperthermic potentiation of chromosome aberrations by anticancer antibiotics. / Vig, B. K.; Cornforth, Michael; Farook, S. A F.

In: Cytogenetics and Cell Genetics, Vol. 33, No. 1-2, 1982, p. 35-41.

Research output: Contribution to journalArticle

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