Hypertonic saline: First-line therapy for cerebral edema?

Wendy C. Ziai, Thomas J K Toung, Anish Bhardwaj

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

This article highlights the experimental and clinical data, controversies and postulated mechanisms surrounding osmotherapy with hypertonic saline (HS) solutions in the neurocritical care arena and builds on previous reviews on the subject. Special attention is focused on HS therapy on commonly encountered clinical paradigms of acute brain injury including traumatic brain injury (TBI), post-operative "retraction edema", intracranial hemorrhage (ICH), tumor-associated cerebral edema, and ischemia associated with ischemic stroke.

Original languageEnglish (US)
Pages (from-to)157-166
Number of pages10
JournalJournal of the Neurological Sciences
Volume261
Issue number1-2
DOIs
StatePublished - Oct 15 2007
Externally publishedYes

Fingerprint

Hypertonic Saline Solutions
Intracranial Hemorrhages
Brain Edema
Brain Ischemia
Brain Injuries
Edema
Stroke
Neoplasms
Therapeutics
Traumatic Brain Injury

Keywords

  • Cerebral edema
  • Hypertonic saline
  • Intracranial hemorrhage

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Hypertonic saline : First-line therapy for cerebral edema? / Ziai, Wendy C.; Toung, Thomas J K; Bhardwaj, Anish.

In: Journal of the Neurological Sciences, Vol. 261, No. 1-2, 15.10.2007, p. 157-166.

Research output: Contribution to journalArticle

Ziai, Wendy C. ; Toung, Thomas J K ; Bhardwaj, Anish. / Hypertonic saline : First-line therapy for cerebral edema?. In: Journal of the Neurological Sciences. 2007 ; Vol. 261, No. 1-2. pp. 157-166.
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