Hypertriglyceridemia and peripheral neuropathy in neurologically asymptomatic patients

Hania Kassem, Sami T. Azar, Mira S. Zantout, Raja A. Sawaya

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objectives: In this study we intended to find a correlation between hypertriglyceridemia and peripheral neuropathy (PN) in patients with a high triglyceride level and no neurological complaints. Methods: We rec ruited 24 patients (21 males and 3 females) having a triglyceride level above 300 mg/dl with no neurologic complaints and none of the other common causes of PN and they underwent an electroneurographic study. The distal motor or sensory latencies (DL), motor or sensory conduction velocities (CV), and motor or sensory amplitudes (AMP) were collected for the peroneal, posterior tibial, sural, median, and ulnar nerves and were considered abnormal if they fall above or below 2 standard deviations of reference values. Results: Our results show that 70.8% of the patients had a significant delay in the DL of the sural nerves and 66.7% had a significant delay in the DL of the median sensory fibers. 54.2% of the patients had a significant decrease in the motor CV in the posterior tibial nerves and 33.3% had a significant decrease in the sensory CV in the sural nerves. The means of the DL and CV were significantly different from reference values in most of the nerves. Amplitudes were the least if at all affected. Conclusion: The pattern of the abnormalities affecting more t he DL, the sensory nerves and the longer nerves of the lower extremities is suggestive of an early axonal polyneuropathy. We conclude that hypertriglyceridemia affects conduction parameters in peripheral nerves in a trend suggestive of early peripheral neuropathy.

Original languageEnglish (US)
Pages (from-to)775-779
Number of pages5
JournalNeuroendocrinology Letters
Volume26
Issue number6
StatePublished - Dec 2005
Externally publishedYes

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Hypertriglyceridemia
Peripheral Nervous System Diseases
Sural Nerve
Tibial Nerve
Reference Values
Triglycerides
Ulnar Nerve
Polyneuropathies
Median Nerve
Peripheral Nerves
Nervous System
Lower Extremity

Keywords

  • Electrophysiological parameters
  • Peripheral neuropathy
  • Triglycerides

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Hypertriglyceridemia and peripheral neuropathy in neurologically asymptomatic patients. / Kassem, Hania; Azar, Sami T.; Zantout, Mira S.; Sawaya, Raja A.

In: Neuroendocrinology Letters, Vol. 26, No. 6, 12.2005, p. 775-779.

Research output: Contribution to journalArticle

Kassem, Hania ; Azar, Sami T. ; Zantout, Mira S. ; Sawaya, Raja A. / Hypertriglyceridemia and peripheral neuropathy in neurologically asymptomatic patients. In: Neuroendocrinology Letters. 2005 ; Vol. 26, No. 6. pp. 775-779.
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