TY - JOUR
T1 - Hypertrophic scarring
T2 - the greatest unmet challenge after burn injury
AU - Finnerty, Celeste C.
AU - Jeschke, Marc G.
AU - Branski, Ludwik K.
AU - Barret, Juan P.
AU - Dziewulski, Peter
AU - Herndon, David
N1 - Funding Information:
This project was supported by grants from the National Institutes of Health (R01-GM-056687 and P50-GM-060338 to DNH, R01-GM-112936 to CCF); from the Shriners Hospitals for Children (84080, 71008, and 79141 to DNH, 84202 to CCF, RO1-GM-087285 to MGJ); from the Anderson Foundation and the Gillson Longenbaugh Foundation to CCF and DNH; and from CIHR Funds (123336 to MGJ); and from CFI Leader's Opportunity Fund (Project #25407 to MGJ). Additional support was provided by UTMB's Institute for Translational Sciences, supported in part by a Clinical and Translational Science Award (UL1TR000071) from the National Center for Advancing Translational Sciences (NIH). We also thank Kasie Cole, Deborah Benjamin, and Holly Goode (University of Texas Medical Branch) for their assistance related to this manuscript.
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Improvements in acute burn care have enabled patients to survive massive burns that would have once been fatal. Now up to 70% of patients develop hypertrophic scars after burns. The functional and psychosocial sequelae remain a major rehabilitative challenge, decreasing quality of life and delaying reintegration into society. Approaches to optimise healing potential of burn wounds use targeted wound care and surgery to minimise the development of hypertrophic scarring. Such approaches often fail, and modulation of the established scar is continued although the optimal indication, timing, and combination of therapies have yet to be established. The need for novel treatments is paramount, and future efforts to improve outcomes and quality of life should include optimisation of wound healing to attenuate or prevent hypertrophic scarring, well-designed trials to confirm treatment efficacy, and further elucidation of molecular mechanisms to allow development of new preventive and therapeutic strategies.
AB - Improvements in acute burn care have enabled patients to survive massive burns that would have once been fatal. Now up to 70% of patients develop hypertrophic scars after burns. The functional and psychosocial sequelae remain a major rehabilitative challenge, decreasing quality of life and delaying reintegration into society. Approaches to optimise healing potential of burn wounds use targeted wound care and surgery to minimise the development of hypertrophic scarring. Such approaches often fail, and modulation of the established scar is continued although the optimal indication, timing, and combination of therapies have yet to be established. The need for novel treatments is paramount, and future efforts to improve outcomes and quality of life should include optimisation of wound healing to attenuate or prevent hypertrophic scarring, well-designed trials to confirm treatment efficacy, and further elucidation of molecular mechanisms to allow development of new preventive and therapeutic strategies.
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U2 - 10.1016/S0140-6736(16)31406-4
DO - 10.1016/S0140-6736(16)31406-4
M3 - Review article
C2 - 27707499
AN - SCOPUS:84994904491
SN - 0140-6736
VL - 388
SP - 1427
EP - 1436
JO - The Lancet
JF - The Lancet
IS - 10052
ER -