Hypoglycemic effects and mechanisms of electroacupuncture on insulin resistance

Jieyun Yin, Jian Kuang, Manisha Chandalia, Demidmaa Tuvdendorj, Batbayar Tumurbaatar, Nicola Abate, Jiande D Z Chen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The aim of this study was to investigate effects and mechanisms of electroacupuncture (EA) on blood glucose and insulin sensitivity in mice fed a high-fat diet. Both wild-type (WT) and adipose ectonucleotide pyrophosphate phosphodiesterase (ENPP1) transgenic (TG) mice were fed a high-fat diet for 12 wk; for each mouse, an intraperitoneal glucose tolerance test (IPGTT) and insulin tolerance test (ITT) were performed with or without EA at abdomen or auricular areas. A high-fat diet-induced insulin resistance in both WT and TG mice. In the WT mice, EA at 3 Hz and 15 Hz, but not at 1 Hz or 100 Hz, via CV4+CV12 significantly reduced postprandial glucose levels; EA at 3 Hz was most potent. The glucose level was reduced by 61.7% at 60 min and 74.5% at 120 min with EA at 3 Hz (all P < 0.001 vs. control). Similar hypoglycemic effect was noted in the TG mice. On the contrary, EA at auricular points increased postprandial glucose level (P < 0.03). 4). EA at 3 Hz via CV4+CV12 significantly enhanced the decrease of blood glucose after insulin injection, suggesting improvement of insulin sensitivity. Plasma free fatty acid was significantly suppressed by 42.5% at 15 min and 50.8% at 30 min with EA (P < 0.01) in both WT and TG mice. EA improves glucose tolerance in both WT and TG mice fed a high-fat diet, and the effect is associated with stimulation parameters and acupoints and is probably attributed to the reduction of free fatty acid.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume307
Issue number3
DOIs
StatePublished - 2014

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Electroacupuncture
Hypoglycemic Agents
Insulin Resistance
Transgenic Mice
High Fat Diet
Glucose
Nonesterified Fatty Acids
Blood Glucose
Insulin
Acupuncture Points
Phosphoric Diester Hydrolases
Glucose Tolerance Test
Abdomen
Injections

Keywords

  • Electroacupuncture
  • Free fatty acid
  • Glucose
  • Insulin resistance
  • Vagal activity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Hypoglycemic effects and mechanisms of electroacupuncture on insulin resistance. / Yin, Jieyun; Kuang, Jian; Chandalia, Manisha; Tuvdendorj, Demidmaa; Tumurbaatar, Batbayar; Abate, Nicola; Chen, Jiande D Z.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 307, No. 3, 2014.

Research output: Contribution to journalArticle

Yin, Jieyun ; Kuang, Jian ; Chandalia, Manisha ; Tuvdendorj, Demidmaa ; Tumurbaatar, Batbayar ; Abate, Nicola ; Chen, Jiande D Z. / Hypoglycemic effects and mechanisms of electroacupuncture on insulin resistance. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2014 ; Vol. 307, No. 3.
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