Hypolipidemic and antioxidant activity of aqueous extract of fruit of Withania coagulans (Stocks) Dunal in cholesterol-fed hyperlipidemic rabbit model

Kirtikar Shukla, Piyush Dikshit, Rimi Shukla, Sonal Sharma, Jasvinder K. Gambhir

Research output: Contribution to journalLetter

13 Scopus citations

Abstract

Withania coagulans (family: Solanaceae, English: Indian Cheese Maker, Hindi: Doda Paneer) fruit is known for its ethanopharmacological significance in health care system of India. Diet rich in high-fat is an important risk factor for diabetes, atherosclerosis and macro and microvascular complications. Treatment with aqueous extract of fruit of W. coagulans (aqWC; 250 mg/kg body weight) in cholesterol-fed animals resulted in significant decrease in the levels of total cholesterol, triacylglycerol, low density lipoprotein, tissue lipid content and acetyl CoA carboxylase activity whereas, the level of high density lipoprotein and activity of HMGCoA reductase also recovered partially. Treatment with aqWC also significantly decreased plasma lipid peroxide levels and increased reduced glutathione and superoxide dismutase activities. These results suggest that the aqueous extract of W. coagulans has potent lipid lowering and antioxidant activities.

Original languageEnglish (US)
Pages (from-to)870-875
Number of pages6
JournalIndian Journal of Experimental Biology
Volume52
Issue number9
StatePublished - Sep 1 2014

Keywords

  • Hypercholesterolemia
  • Lipid lowering activities
  • Lipid metabolism
  • Oxidative stress
  • Withania coagulans

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology

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