Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats

Zoltán Benyó; Csaba Szabó; Bauke T. Stuiver; Béla Bohus; Péter Sándor

doi:10.1016/0304-3940(95)11981-2

Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats

Zoltán Benyó, Csaba Szabó, Bauke T. Stuiver, Béla Bohus, Péter Sándor

Research output: Contribution to journal › Article

13 Scopus citations

Abstract

The effect of the chronic oral application of N^G-nitro-l-arginine methyl ester (l-NAME), a potent inhibitor of nitric oxide (NO) production, was studied on hypothalamic blood flow (HBF) and hypothalamic nitric oxide synthase (NOS) activity in rats. l-NAME was dissolved in the drinking water, in a concentration of 0.1 mg/ml, and was administered for 1 week. In the chronic l-NAME pretreated animals significantly reduced hypothalamic NOS activity and marked hypothalamic vasoconstriction were observed, the latter of which was counteracted by sustained systemic arterial hypertension, while HBF remained unchanged. The present model of chronic NOS blockade may be useful to assess the physiological functions of NO in the regulation of cerebral blood flow in the normally perfused brain.

Original language	English (US)
Pages (from-to)	127-130
Number of pages	4
Journal	Neuroscience Letters
Volume	198
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(95)11981-2
State	Published - Sep 29 1995

Keywords

Cerebral blood flow
Chronic nitric oxide blockade
Hypertension
Hypothalamus
N-nitro-l-arginine methyl ester
Nitric oxide synthase activity
Rat
Vasoconstriction

ASJC Scopus subject areas

Neuroscience(all)

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Benyó, Z., Szabó, C., Stuiver, B. T., Bohus, B., & Sándor, P. (1995). Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats. Neuroscience Letters, 198(2), 127-130. https://doi.org/10.1016/0304-3940(95)11981-2

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abstract = "The effect of the chronic oral application of NG-nitro-l-arginine methyl ester (l-NAME), a potent inhibitor of nitric oxide (NO) production, was studied on hypothalamic blood flow (HBF) and hypothalamic nitric oxide synthase (NOS) activity in rats. l-NAME was dissolved in the drinking water, in a concentration of 0.1 mg/ml, and was administered for 1 week. In the chronic l-NAME pretreated animals significantly reduced hypothalamic NOS activity and marked hypothalamic vasoconstriction were observed, the latter of which was counteracted by sustained systemic arterial hypertension, while HBF remained unchanged. The present model of chronic NOS blockade may be useful to assess the physiological functions of NO in the regulation of cerebral blood flow in the normally perfused brain.",

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AU - Benyó, Zoltán

AU - Szabó, Csaba

AU - Stuiver, Bauke T.

AU - Bohus, Béla

AU - Sándor, Péter

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KW - Hypothalamus

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KW - Vasoconstriction

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