Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats

Zoltán Benyó, Csaba Szabo, Bauke T. Stuiver, Béla Bohus, Péter Sándor

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The effect of the chronic oral application of NG-nitro-l-arginine methyl ester (l-NAME), a potent inhibitor of nitric oxide (NO) production, was studied on hypothalamic blood flow (HBF) and hypothalamic nitric oxide synthase (NOS) activity in rats. l-NAME was dissolved in the drinking water, in a concentration of 0.1 mg/ml, and was administered for 1 week. In the chronic l-NAME pretreated animals significantly reduced hypothalamic NOS activity and marked hypothalamic vasoconstriction were observed, the latter of which was counteracted by sustained systemic arterial hypertension, while HBF remained unchanged. The present model of chronic NOS blockade may be useful to assess the physiological functions of NO in the regulation of cerebral blood flow in the normally perfused brain.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalNeuroscience Letters
Volume198
Issue number2
DOIs
StatePublished - Sep 29 1995
Externally publishedYes

Fingerprint

Nitric Oxide Synthase
Cerebrovascular Circulation
Nitric Oxide
Vasoconstriction
Drinking Water
Hypertension
Brain
arginine methyl ester

Keywords

  • Cerebral blood flow
  • Chronic nitric oxide blockade
  • Hypertension
  • Hypothalamus
  • N-nitro-l-arginine methyl ester
  • Nitric oxide synthase activity
  • Rat
  • Vasoconstriction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats. / Benyó, Zoltán; Szabo, Csaba; Stuiver, Bauke T.; Bohus, Béla; Sándor, Péter.

In: Neuroscience Letters, Vol. 198, No. 2, 29.09.1995, p. 127-130.

Research output: Contribution to journalArticle

Benyó, Zoltán ; Szabo, Csaba ; Stuiver, Bauke T. ; Bohus, Béla ; Sándor, Péter. / Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats. In: Neuroscience Letters. 1995 ; Vol. 198, No. 2. pp. 127-130.
@article{270754d41760492089937916f83a31a7,
title = "Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats",
abstract = "The effect of the chronic oral application of NG-nitro-l-arginine methyl ester (l-NAME), a potent inhibitor of nitric oxide (NO) production, was studied on hypothalamic blood flow (HBF) and hypothalamic nitric oxide synthase (NOS) activity in rats. l-NAME was dissolved in the drinking water, in a concentration of 0.1 mg/ml, and was administered for 1 week. In the chronic l-NAME pretreated animals significantly reduced hypothalamic NOS activity and marked hypothalamic vasoconstriction were observed, the latter of which was counteracted by sustained systemic arterial hypertension, while HBF remained unchanged. The present model of chronic NOS blockade may be useful to assess the physiological functions of NO in the regulation of cerebral blood flow in the normally perfused brain.",
keywords = "Cerebral blood flow, Chronic nitric oxide blockade, Hypertension, Hypothalamus, N-nitro-l-arginine methyl ester, Nitric oxide synthase activity, Rat, Vasoconstriction",
author = "Zolt{\'a}n Beny{\'o} and Csaba Szabo and Stuiver, {Bauke T.} and B{\'e}la Bohus and P{\'e}ter S{\'a}ndor",
year = "1995",
month = "9",
day = "29",
doi = "10.1016/0304-3940(95)11981-2",
language = "English (US)",
volume = "198",
pages = "127--130",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats

AU - Benyó, Zoltán

AU - Szabo, Csaba

AU - Stuiver, Bauke T.

AU - Bohus, Béla

AU - Sándor, Péter

PY - 1995/9/29

Y1 - 1995/9/29

N2 - The effect of the chronic oral application of NG-nitro-l-arginine methyl ester (l-NAME), a potent inhibitor of nitric oxide (NO) production, was studied on hypothalamic blood flow (HBF) and hypothalamic nitric oxide synthase (NOS) activity in rats. l-NAME was dissolved in the drinking water, in a concentration of 0.1 mg/ml, and was administered for 1 week. In the chronic l-NAME pretreated animals significantly reduced hypothalamic NOS activity and marked hypothalamic vasoconstriction were observed, the latter of which was counteracted by sustained systemic arterial hypertension, while HBF remained unchanged. The present model of chronic NOS blockade may be useful to assess the physiological functions of NO in the regulation of cerebral blood flow in the normally perfused brain.

AB - The effect of the chronic oral application of NG-nitro-l-arginine methyl ester (l-NAME), a potent inhibitor of nitric oxide (NO) production, was studied on hypothalamic blood flow (HBF) and hypothalamic nitric oxide synthase (NOS) activity in rats. l-NAME was dissolved in the drinking water, in a concentration of 0.1 mg/ml, and was administered for 1 week. In the chronic l-NAME pretreated animals significantly reduced hypothalamic NOS activity and marked hypothalamic vasoconstriction were observed, the latter of which was counteracted by sustained systemic arterial hypertension, while HBF remained unchanged. The present model of chronic NOS blockade may be useful to assess the physiological functions of NO in the regulation of cerebral blood flow in the normally perfused brain.

KW - Cerebral blood flow

KW - Chronic nitric oxide blockade

KW - Hypertension

KW - Hypothalamus

KW - N-nitro-l-arginine methyl ester

KW - Nitric oxide synthase activity

KW - Rat

KW - Vasoconstriction

UR - http://www.scopus.com/inward/record.url?scp=0028875387&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028875387&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(95)11981-2

DO - 10.1016/0304-3940(95)11981-2

M3 - Article

VL - 198

SP - 127

EP - 130

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -