Abstract
The effect of the chronic oral application of NG-nitro-l-arginine methyl ester (l-NAME), a potent inhibitor of nitric oxide (NO) production, was studied on hypothalamic blood flow (HBF) and hypothalamic nitric oxide synthase (NOS) activity in rats. l-NAME was dissolved in the drinking water, in a concentration of 0.1 mg/ml, and was administered for 1 week. In the chronic l-NAME pretreated animals significantly reduced hypothalamic NOS activity and marked hypothalamic vasoconstriction were observed, the latter of which was counteracted by sustained systemic arterial hypertension, while HBF remained unchanged. The present model of chronic NOS blockade may be useful to assess the physiological functions of NO in the regulation of cerebral blood flow in the normally perfused brain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 127-130 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 198 |
| Issue number | 2 |
| DOIs | |
| State | Published - Sep 29 1995 |
| Externally published | Yes |
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Keywords
- Cerebral blood flow
- Chronic nitric oxide blockade
- Hypertension
- Hypothalamus
- N-nitro-l-arginine methyl ester
- Nitric oxide synthase activity
- Rat
- Vasoconstriction
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats. / Benyó, Zoltán; Szabo, Csaba; Stuiver, Bauke T.; Bohus, Béla; Sándor, Péter.
In: Neuroscience Letters, Vol. 198, No. 2, 29.09.1995, p. 127-130.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats
AU - Benyó, Zoltán
AU - Szabo, Csaba
AU - Stuiver, Bauke T.
AU - Bohus, Béla
AU - Sándor, Péter
PY - 1995/9/29
Y1 - 1995/9/29
N2 - The effect of the chronic oral application of NG-nitro-l-arginine methyl ester (l-NAME), a potent inhibitor of nitric oxide (NO) production, was studied on hypothalamic blood flow (HBF) and hypothalamic nitric oxide synthase (NOS) activity in rats. l-NAME was dissolved in the drinking water, in a concentration of 0.1 mg/ml, and was administered for 1 week. In the chronic l-NAME pretreated animals significantly reduced hypothalamic NOS activity and marked hypothalamic vasoconstriction were observed, the latter of which was counteracted by sustained systemic arterial hypertension, while HBF remained unchanged. The present model of chronic NOS blockade may be useful to assess the physiological functions of NO in the regulation of cerebral blood flow in the normally perfused brain.
AB - The effect of the chronic oral application of NG-nitro-l-arginine methyl ester (l-NAME), a potent inhibitor of nitric oxide (NO) production, was studied on hypothalamic blood flow (HBF) and hypothalamic nitric oxide synthase (NOS) activity in rats. l-NAME was dissolved in the drinking water, in a concentration of 0.1 mg/ml, and was administered for 1 week. In the chronic l-NAME pretreated animals significantly reduced hypothalamic NOS activity and marked hypothalamic vasoconstriction were observed, the latter of which was counteracted by sustained systemic arterial hypertension, while HBF remained unchanged. The present model of chronic NOS blockade may be useful to assess the physiological functions of NO in the regulation of cerebral blood flow in the normally perfused brain.
KW - Cerebral blood flow
KW - Chronic nitric oxide blockade
KW - Hypertension
KW - Hypothalamus
KW - N-nitro-l-arginine methyl ester
KW - Nitric oxide synthase activity
KW - Rat
KW - Vasoconstriction
UR - http://www.scopus.com/inward/record.url?scp=0028875387&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028875387&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(95)11981-2
DO - 10.1016/0304-3940(95)11981-2
M3 - Article
VL - 198
SP - 127
EP - 130
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -