Hypoxia ischemia-mediated cell death in neonatal rat brain

Martin B. Gill, J. Regino Perez-Polo

    Research output: Contribution to journalArticle

    43 Citations (Scopus)

    Abstract

    The examination of Bcl-2-associated X protein (Bax) protein's role in the activation of cognate nuclear, mitochondrial and ER cell death signaling cascades and the resulting effects on cell death phenotype in the brain after neonatal hypoxia-ischemia (HI) requires an understanding of neonatal HI insult and progression, as well as, its dysfunctional outcomes. In addition, knowledge of key concepts of oxidative stress, a major injurious component of HI, and the different cell death phenotypes (i.e. apoptosis and necrosis) will aid the design of appropriate useful experimental paradigms. Here we discuss organelle cell death signaling cascades in the context of the different cell death phenotypes associated with animal models of neonatal hypoxia ischemia and tissue culture models used in the study of hypoxia ischemia, focusing on the intracellular shifts of the Bcl-2 associated X protein (Bax) in the hypoxic brain.

    Original languageEnglish (US)
    Pages (from-to)2379-2389
    Number of pages11
    JournalNeurochemical Research
    Volume33
    Issue number12
    DOIs
    StatePublished - Dec 2008

    Fingerprint

    Cell death
    Rats
    Brain
    Cell Death
    Ischemia
    bcl-2-Associated X Protein
    Phenotype
    Tissue culture
    Oxidative stress
    Organelles
    Animals
    Oxidative Stress
    Necrosis
    Animal Models
    Chemical activation
    Hypoxia
    Apoptosis
    Proteins

    Keywords

    • Apoptosis
    • Bax
    • Cell death
    • Hypoxia
    • Ischemia
    • Low birth weight babies
    • Necrosis
    • Neonatal
    • Organelles

    ASJC Scopus subject areas

    • Cellular and Molecular Neuroscience
    • Biochemistry

    Cite this

    Hypoxia ischemia-mediated cell death in neonatal rat brain. / Gill, Martin B.; Perez-Polo, J. Regino.

    In: Neurochemical Research, Vol. 33, No. 12, 12.2008, p. 2379-2389.

    Research output: Contribution to journalArticle

    Gill, Martin B. ; Perez-Polo, J. Regino. / Hypoxia ischemia-mediated cell death in neonatal rat brain. In: Neurochemical Research. 2008 ; Vol. 33, No. 12. pp. 2379-2389.
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