Iatrogenic Conditions

Diana Palacio, Usha Jayagurunathan, Girish S. Shroff, Patricia M. de Groot, Mylene T. Truong, Cesar A. Moran

Research output: Chapter in Book/Report/Conference proceedingChapter


Over a thousand medications are known to have the potential to result in lung injury. The constant development of new pharmaceuticals capable of inducing lung damage has grown to a point where it is a challenge to update the information. Fortunately, a comprehensive catalog can be found in the International Database “Pneumotox” (www.pneumotox.com). In this initiative, the imaging characteristics and/or suspected substance can be thoroughly researched, including common and unusual manifestations. It is important to be aware of the medication groups most likely to be associated with lung injury: antineoplastic drugs, antirheumatic medications, antibiotics, nonsteroidal anti-inflammatory agents (NSAIDs), antipsychotics, and antiarrhythmics. In the oncologic setting, it is important to be familiar with the variety of treatment-related side effects to avoid misinterpretation as tumor progression and to ensure appropriate management. Treatment options include chemotherapy, targeted therapy, immunotherapy, and radiation therapy. While recent advances in high-precision radiation therapy techniques such as stereotactic body radiotherapy (SBRT), intensity-modulated radiotherapy (IMRT), and proton therapy (PT) have decreased the radiation dose to normal tissues during treatment, radiation-induced lung injury usually occurs to some degree.

Original languageEnglish (US)
Title of host publicationThe Thorax
Subtitle of host publicationMedical, Radiological, and Pathological Assessment
PublisherSpringer International Publishing
Number of pages35
ISBN (Electronic)9783031210402
ISBN (Print)9783031210396
StatePublished - Jan 1 2023


  • Diffuse alveolar damage
  • Hypersensitivity pneumonitis
  • Immunotherapy
  • Organizing pneumonia
  • Pulmonary drug toxicity
  • Radiation fibrosis
  • Radiation pneumonitis
  • Radiation therapy
  • Targeted therapy

ASJC Scopus subject areas

  • General Medicine


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