Ibuprofen as a template molecule for drug design against Ebola virus

Slobodan Paessler, Cheng Huang, Milan Sencanski, Nevena Veljkovic, Vladimir Perovic, Sanja Glisic, Veljko Veljkovic

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The Ebola virus outbreak in West Africa 2015 and Congo 2017, point out an urgent need for development of drugs against this important pathogen. Previously, by repurposing virtual screening of 6438 drugs from DrugBank, ibuprofen was selected as a possible inhibitor of the Ebola virus infection. The results of an additional docking analysis as well as experimental results showing measurable anti-Ebola effect of ibuprofen in cell culture suggest ibuprofen as a promising molecular template for the development of drugs for treatment of the infection by Ebola virus.

Original languageEnglish (US)
Pages (from-to)947-953
Number of pages7
JournalFrontiers in Bioscience - Landmark
Volume23
Issue number5
DOIs
StatePublished - Jan 1 2018

Keywords

  • Drug Repositioning
  • Ebola virus
  • Entry Inhibitors
  • Glycoprotein
  • Ibuprofen

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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