Ibuprofen as a template molecule for drug design against Ebola virus

Slobodan Paessler, Cheng Huang, Milan Sencanski, Nevena Veljkovic, Vladimir Perovic, Sanja Glisic, Veljko Veljkovic

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The Ebola virus outbreak in West Africa 2015 and Congo 2017, point out an urgent need for development of drugs against this important pathogen. Previously, by repurposing virtual screening of 6438 drugs from DrugBank, ibuprofen was selected as a possible inhibitor of the Ebola virus infection. The results of an additional docking analysis as well as experimental results showing measurable anti-Ebola effect of ibuprofen in cell culture suggest ibuprofen as a promising molecular template for the development of drugs for treatment of the infection by Ebola virus.

Original languageEnglish (US)
Pages (from-to)947-953
Number of pages7
JournalFrontiers in Bioscience - Landmark
Volume23
Issue number5
StatePublished - Jan 1 2018

Fingerprint

Ebolavirus
Ibuprofen
Drug Design
Ebola Hemorrhagic Fever
Viruses
Molecules
Pharmaceutical Preparations
Congo
Preclinical Drug Evaluations
Western Africa
Pathogens
Cell culture
Disease Outbreaks
Screening
Cell Culture Techniques

Keywords

  • Drug Repositioning
  • Ebola virus
  • Entry Inhibitors
  • Glycoprotein
  • Ibuprofen

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Paessler, S., Huang, C., Sencanski, M., Veljkovic, N., Perovic, V., Glisic, S., & Veljkovic, V. (2018). Ibuprofen as a template molecule for drug design against Ebola virus. Frontiers in Bioscience - Landmark, 23(5), 947-953.

Ibuprofen as a template molecule for drug design against Ebola virus. / Paessler, Slobodan; Huang, Cheng; Sencanski, Milan; Veljkovic, Nevena; Perovic, Vladimir; Glisic, Sanja; Veljkovic, Veljko.

In: Frontiers in Bioscience - Landmark, Vol. 23, No. 5, 01.01.2018, p. 947-953.

Research output: Contribution to journalArticle

Paessler, S, Huang, C, Sencanski, M, Veljkovic, N, Perovic, V, Glisic, S & Veljkovic, V 2018, 'Ibuprofen as a template molecule for drug design against Ebola virus', Frontiers in Bioscience - Landmark, vol. 23, no. 5, pp. 947-953.
Paessler S, Huang C, Sencanski M, Veljkovic N, Perovic V, Glisic S et al. Ibuprofen as a template molecule for drug design against Ebola virus. Frontiers in Bioscience - Landmark. 2018 Jan 1;23(5):947-953.
Paessler, Slobodan ; Huang, Cheng ; Sencanski, Milan ; Veljkovic, Nevena ; Perovic, Vladimir ; Glisic, Sanja ; Veljkovic, Veljko. / Ibuprofen as a template molecule for drug design against Ebola virus. In: Frontiers in Bioscience - Landmark. 2018 ; Vol. 23, No. 5. pp. 947-953.
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