Ibuprofen improves cerebral blood flow after global cerebral ischemia in dogs

S. C. Grice, E. T. Chappell, Donald Prough, J. M. Whitley, M. Su, W. D. Watkins

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In a canine model of global cerebral ischemia, 6 dogs received a saline placebo prior to the event and 5 received 12.5 mg/kg ibuprofen. Cerebral venous outflow from the confluence of the sagittal and transverse sinuses, systolic and diastolic arterial pressure, cardiac output, pH, Pa(CO2), Pa(O2), and arterial and sagittal sinus thromboxane B2 and 6-keto-PGF(1α) were measured at intervals up to 120 minutes thereafter. Postischemic cerebral hypoperfusion was significantly improved in the ibuprofen pretreatment group. Control dogs showed significant increases in sagittal sinus postischemic thromboxane B2 concentrations, but pretreated dogs showed nearly complete inhibition of postischemic thromboxane B2 production. Pretreated dogs also had significantly lower levels of 6-keto-PGF(1α) from the sagittal sinus. There were no significant differences in the other variables at any interval. We conclude that ibuprofen ameliorates postischemic cerebral hypoperfusion, and that this improvement is associated with decreased sagittal sinus levels of thromboxane B2 and 6-keto-PGF(1α).

Original languageEnglish (US)
Pages (from-to)787-791
Number of pages5
JournalStroke
Volume18
Issue number4
StatePublished - 1987
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Thromboxane B2
Ibuprofen
Brain Ischemia
Prostaglandins F
Dogs
Transverse Sinuses
Cardiac Output
Canidae
Arterial Pressure
Placebos
Blood Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Grice, S. C., Chappell, E. T., Prough, D., Whitley, J. M., Su, M., & Watkins, W. D. (1987). Ibuprofen improves cerebral blood flow after global cerebral ischemia in dogs. Stroke, 18(4), 787-791.

Ibuprofen improves cerebral blood flow after global cerebral ischemia in dogs. / Grice, S. C.; Chappell, E. T.; Prough, Donald; Whitley, J. M.; Su, M.; Watkins, W. D.

In: Stroke, Vol. 18, No. 4, 1987, p. 787-791.

Research output: Contribution to journalArticle

Grice, SC, Chappell, ET, Prough, D, Whitley, JM, Su, M & Watkins, WD 1987, 'Ibuprofen improves cerebral blood flow after global cerebral ischemia in dogs', Stroke, vol. 18, no. 4, pp. 787-791.
Grice SC, Chappell ET, Prough D, Whitley JM, Su M, Watkins WD. Ibuprofen improves cerebral blood flow after global cerebral ischemia in dogs. Stroke. 1987;18(4):787-791.
Grice, S. C. ; Chappell, E. T. ; Prough, Donald ; Whitley, J. M. ; Su, M. ; Watkins, W. D. / Ibuprofen improves cerebral blood flow after global cerebral ischemia in dogs. In: Stroke. 1987 ; Vol. 18, No. 4. pp. 787-791.
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