Ibuprofen improves cerebral blood flow after global cerebral ischemia in dogs

Stephen C. Grice, E. T. Chappell, Donald S. Prough, John M. Whitley, Michael Su, W. David Watkins

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


In a canine model of global cerebral ischemia, 6 dogs received a saline placebo prior to the event and 5 received 12.5 mg/kg ibuprofen. Cerebral venous outflow from the confluence of the sagittal and transverse sinuses, systolic and diastolic arterial pressure, cardiac output, pH, Paco2, Pao2, and arterial and sagittal sinus thromboxane B2 and 6-keto-PGF were measured at intervals up to 120 minutes thereafter. Postischemi ccerebral hypo perfusion was significantly unproved in the ibuprofen pretreatment group. Control dogs showed significant increases in sagittal sinus post ischemic thromboxane B2 concentrations, but pretreated dogs showed nearly complete inhibition of postischemic thromboxane B2 production. Pretreated dogs also had significantly lower levels of 6-keto-PGF from the sagittal sinus. There were no significant differences in the other variables at any interval. We conclude that ibuprofen ameliorates postischemic cerebral hypoperfusion, and that this improvement is associated with decreased sagittal sinus levels of thromboxane B2 and 6-keto-PGF.

Original languageEnglish (US)
Pages (from-to)787-791
Number of pages5
Issue number4
StatePublished - 1987
Externally publishedYes


  • Eicosanoid
  • Global cerebral ischemia
  • Ibuprofen
  • Prostacydin
  • Prostaglandins
  • Thromboxane

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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