Ibuprofen therapy in experimental porcine gram-negative septic shock

M. Pamela Griffin; Dennis C. Gore; Thom E. Lobeb; John F. Flynn; Daniel L. Traber; David N. Herndon

doi:10.1016/0300-9572(91)90066-8

Ibuprofen therapy in experimental porcine gram-negative septic shock

M. Pamela Griffin, Dennis C. Gore, Thom E. Lobeb, John F. Flynn, Daniel L. Traber, David N. Herndon

Surgery

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3 Scopus citations

Abstract

To evaluate the effects of ibuprofen on gram-negative septic shock, immature piglets were subjected to fecal-Escherichia coli peritonitis. Group I (n = 5) received a 12.5 mg/kg bolus of ibuprofen in 0.9% benzyl alcohol, followed by a continuous infusion of 6.25 mg/kg/h. Group II (n = 5) received the vehicle, benzyl alcohol, and Group III (n = 5) received lactated Ringer's solution. Mean survival times among the three groups were not significantly different. Ibuprofen-treated animals had a mean survival time (± S.E.M.) of 17.1 ± 2 h vs. 19.2 ± 2.4 h in the benzyl alcohol group and 15.7 ± 2.7 h in the animals receiving lactated Ringer's solution. Thromboxane B₂ levels were not significantly different in the treatment vs. non-treatment groups while 6-keto-PGF_1a levels were significantly lower in the ibuprofen-treated animals. Neutropenia and thrombocytopenia were not prevented by treatment with ibuprofen.

Original language	English (US)
Pages (from-to)	75-83
Number of pages	9
Journal	Resuscitation
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/0300-9572(91)90066-8
State	Published - Aug 1991

Keywords

Cyclooxygenase inhibitors
Escherichia coli
Peritonitis
Prostacyclin
Sepsis
Thromboxane

ASJC Scopus subject areas

Emergency Medicine
Emergency
Cardiology and Cardiovascular Medicine

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10.1016/0300-9572(91)90066-8

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title = "Ibuprofen therapy in experimental porcine gram-negative septic shock",

abstract = "To evaluate the effects of ibuprofen on gram-negative septic shock, immature piglets were subjected to fecal-Escherichia coli peritonitis. Group I (n = 5) received a 12.5 mg/kg bolus of ibuprofen in 0.9% benzyl alcohol, followed by a continuous infusion of 6.25 mg/kg/h. Group II (n = 5) received the vehicle, benzyl alcohol, and Group III (n = 5) received lactated Ringer's solution. Mean survival times among the three groups were not significantly different. Ibuprofen-treated animals had a mean survival time (± S.E.M.) of 17.1 ± 2 h vs. 19.2 ± 2.4 h in the benzyl alcohol group and 15.7 ± 2.7 h in the animals receiving lactated Ringer's solution. Thromboxane B2 levels were not significantly different in the treatment vs. non-treatment groups while 6-keto-PGF1a levels were significantly lower in the ibuprofen-treated animals. Neutropenia and thrombocytopenia were not prevented by treatment with ibuprofen.",

keywords = "Cyclooxygenase inhibitors, Escherichia coli, Peritonitis, Prostacyclin, Sepsis, Thromboxane",

author = "Griffin, {M. Pamela} and Gore, {Dennis C.} and Lobeb, {Thom E.} and Flynn, {John F.} and Traber, {Daniel L.} and Herndon, {David N.}",

year = "1991",

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AU - Griffin, M. Pamela

AU - Gore, Dennis C.

AU - Lobeb, Thom E.

AU - Flynn, John F.

AU - Traber, Daniel L.

AU - Herndon, David N.

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N2 - To evaluate the effects of ibuprofen on gram-negative septic shock, immature piglets were subjected to fecal-Escherichia coli peritonitis. Group I (n = 5) received a 12.5 mg/kg bolus of ibuprofen in 0.9% benzyl alcohol, followed by a continuous infusion of 6.25 mg/kg/h. Group II (n = 5) received the vehicle, benzyl alcohol, and Group III (n = 5) received lactated Ringer's solution. Mean survival times among the three groups were not significantly different. Ibuprofen-treated animals had a mean survival time (± S.E.M.) of 17.1 ± 2 h vs. 19.2 ± 2.4 h in the benzyl alcohol group and 15.7 ± 2.7 h in the animals receiving lactated Ringer's solution. Thromboxane B2 levels were not significantly different in the treatment vs. non-treatment groups while 6-keto-PGF1a levels were significantly lower in the ibuprofen-treated animals. Neutropenia and thrombocytopenia were not prevented by treatment with ibuprofen.

AB - To evaluate the effects of ibuprofen on gram-negative septic shock, immature piglets were subjected to fecal-Escherichia coli peritonitis. Group I (n = 5) received a 12.5 mg/kg bolus of ibuprofen in 0.9% benzyl alcohol, followed by a continuous infusion of 6.25 mg/kg/h. Group II (n = 5) received the vehicle, benzyl alcohol, and Group III (n = 5) received lactated Ringer's solution. Mean survival times among the three groups were not significantly different. Ibuprofen-treated animals had a mean survival time (± S.E.M.) of 17.1 ± 2 h vs. 19.2 ± 2.4 h in the benzyl alcohol group and 15.7 ± 2.7 h in the animals receiving lactated Ringer's solution. Thromboxane B2 levels were not significantly different in the treatment vs. non-treatment groups while 6-keto-PGF1a levels were significantly lower in the ibuprofen-treated animals. Neutropenia and thrombocytopenia were not prevented by treatment with ibuprofen.

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KW - Sepsis

KW - Thromboxane

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Ibuprofen therapy in experimental porcine gram-negative septic shock

Abstract

Keywords

ASJC Scopus subject areas

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