Ibuprofen therapy in experimental porcine gram-negative septic shock

M. Pamela Griffin, Dennis C. Gore, Thom E. Lobeb, John F. Flynn, Daniel L. Traber, David N. Herndon

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3 Scopus citations

Abstract

To evaluate the effects of ibuprofen on gram-negative septic shock, immature piglets were subjected to fecal-Escherichia coli peritonitis. Group I (n = 5) received a 12.5 mg/kg bolus of ibuprofen in 0.9% benzyl alcohol, followed by a continuous infusion of 6.25 mg/kg/h. Group II (n = 5) received the vehicle, benzyl alcohol, and Group III (n = 5) received lactated Ringer's solution. Mean survival times among the three groups were not significantly different. Ibuprofen-treated animals had a mean survival time (± S.E.M.) of 17.1 ± 2 h vs. 19.2 ± 2.4 h in the benzyl alcohol group and 15.7 ± 2.7 h in the animals receiving lactated Ringer's solution. Thromboxane B2 levels were not significantly different in the treatment vs. non-treatment groups while 6-keto-PGF1a levels were significantly lower in the ibuprofen-treated animals. Neutropenia and thrombocytopenia were not prevented by treatment with ibuprofen.

Original languageEnglish (US)
Pages (from-to)75-83
Number of pages9
JournalResuscitation
Volume22
Issue number1
DOIs
StatePublished - Aug 1991

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Keywords

  • Cyclooxygenase inhibitors
  • Escherichia coli
  • Peritonitis
  • Prostacyclin
  • Sepsis
  • Thromboxane

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

Cite this

Griffin, M. P., Gore, D. C., Lobeb, T. E., Flynn, J. F., Traber, D. L., & Herndon, D. N. (1991). Ibuprofen therapy in experimental porcine gram-negative septic shock. Resuscitation, 22(1), 75-83. https://doi.org/10.1016/0300-9572(91)90066-8