Ibuprofen therapy in experimental porcine gram-negative septic shock

M. Pamela Griffin, Dennis Gore, Thom E. Lobeb, John F. Flynn, Daniel L. Traber, David Herndon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To evaluate the effects of ibuprofen on gram-negative septic shock, immature piglets were subjected to fecal-Escherichia coli peritonitis. Group I (n = 5) received a 12.5 mg/kg bolus of ibuprofen in 0.9% benzyl alcohol, followed by a continuous infusion of 6.25 mg/kg/h. Group II (n = 5) received the vehicle, benzyl alcohol, and Group III (n = 5) received lactated Ringer's solution. Mean survival times among the three groups were not significantly different. Ibuprofen-treated animals had a mean survival time (± S.E.M.) of 17.1 ± 2 h vs. 19.2 ± 2.4 h in the benzyl alcohol group and 15.7 ± 2.7 h in the animals receiving lactated Ringer's solution. Thromboxane B2 levels were not significantly different in the treatment vs. non-treatment groups while 6-keto-PGF1a levels were significantly lower in the ibuprofen-treated animals. Neutropenia and thrombocytopenia were not prevented by treatment with ibuprofen.

Original languageEnglish (US)
Pages (from-to)75-83
Number of pages9
JournalResuscitation
Volume22
Issue number1
DOIs
StatePublished - 1991

Fingerprint

Investigational Therapies
Ibuprofen
Septic Shock
Benzyl Alcohol
Swine
Thromboxane B2
Neutropenia
Peritonitis
Thrombocytopenia
Escherichia coli
Therapeutics

Keywords

  • Cyclooxygenase inhibitors
  • Escherichia coli
  • Peritonitis
  • Prostacyclin
  • Sepsis
  • Thromboxane

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Nursing(all)

Cite this

Griffin, M. P., Gore, D., Lobeb, T. E., Flynn, J. F., Traber, D. L., & Herndon, D. (1991). Ibuprofen therapy in experimental porcine gram-negative septic shock. Resuscitation, 22(1), 75-83. https://doi.org/10.1016/0300-9572(91)90066-8

Ibuprofen therapy in experimental porcine gram-negative septic shock. / Griffin, M. Pamela; Gore, Dennis; Lobeb, Thom E.; Flynn, John F.; Traber, Daniel L.; Herndon, David.

In: Resuscitation, Vol. 22, No. 1, 1991, p. 75-83.

Research output: Contribution to journalArticle

Griffin, MP, Gore, D, Lobeb, TE, Flynn, JF, Traber, DL & Herndon, D 1991, 'Ibuprofen therapy in experimental porcine gram-negative septic shock', Resuscitation, vol. 22, no. 1, pp. 75-83. https://doi.org/10.1016/0300-9572(91)90066-8
Griffin, M. Pamela ; Gore, Dennis ; Lobeb, Thom E. ; Flynn, John F. ; Traber, Daniel L. ; Herndon, David. / Ibuprofen therapy in experimental porcine gram-negative septic shock. In: Resuscitation. 1991 ; Vol. 22, No. 1. pp. 75-83.
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