ICAM-1 expression in corneal epithelium of a patient with vernal keratoconjunctivitis: Case report

Kuljit S. Gill, Judith Yannariello-Brown, Janak Patel, Natsuki Nakajima, Srinivasan Rajaraman, Stefan D. Trocmé

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Recent reports have demonstrated the expression of intercellular adhesion molecule-1 (ICAM-1; CD54) on the epithelium in various allergic diseases and inflammatory conditions, including the bronchial epithelium of patients with allergic asthma, conjunctival epithelium of allergic patients after allergen-specific challenge, and corneal epithelium of rejected corneal allografts. We investigated the presence of ICAM-1 expression on the corneal epithelium from a patient with vernal keratoconjunctivitis (VKC). Immunohistochemical staining of the diseased cornea demonstrated abundant ICAM-1 expression on the corneal epithelium. Immunoreactive ICAM-1 appeared to localize primarily to the cells of the basal and middle layers of the corneal epithelium. No staining was detected on the ocular surface epithelium. The normal, healthy cornea demonstrated no significant ICAM-1 expression on any of the epithelial layers, similar to that previously reported. To the best of our knowledge, this is the first report of ICAM-1 expression on the corneal epithelium from a patient with VKC.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalCornea
Volume16
Issue number1
StatePublished - Jan 1 1997

Keywords

  • Allergy
  • CD54
  • Corneal epithelium
  • Inflammation
  • Intercellular adhesion molecule-1
  • Vernal keratoconjunctivitis

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'ICAM-1 expression in corneal epithelium of a patient with vernal keratoconjunctivitis: Case report'. Together they form a unique fingerprint.

  • Cite this

    Gill, K. S., Yannariello-Brown, J., Patel, J., Nakajima, N., Rajaraman, S., & Trocmé, S. D. (1997). ICAM-1 expression in corneal epithelium of a patient with vernal keratoconjunctivitis: Case report. Cornea, 16(1), 107-111.