Abstract
Recent reports have demonstrated the expression of intercellular adhesion molecule-1 (ICAM-1; CD54) on the epithelium in various allergic diseases and inflammatory conditions, including the bronchial epithelium of patients with allergic asthma, conjunctival epithelium of allergic patients after allergen-specific challenge, and corneal epithelium of rejected corneal allografts. We investigated the presence of ICAM-1 expression on the corneal epithelium from a patient with vernal keratoconjunctivitis (VKC). Immunohistochemical staining of the diseased cornea demonstrated abundant ICAM-1 expression on the corneal epithelium. Immunoreactive ICAM-1 appeared to localize primarily to the cells of the basal and middle layers of the corneal epithelium. No staining was detected on the ocular surface epithelium. The normal, healthy cornea demonstrated no significant ICAM-1 expression on any of the epithelial layers, similar to that previously reported. To the best of our knowledge, this is the first report of ICAM-1 expression on the corneal epithelium from a patient with VKC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 107-111 |
| Number of pages | 5 |
| Journal | Cornea |
| Volume | 16 |
| Issue number | 1 |
| State | Published - Jan 1997 |
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Keywords
- Allergy
- CD54
- Corneal epithelium
- Inflammation
- Intercellular adhesion molecule-1
- Vernal keratoconjunctivitis
ASJC Scopus subject areas
- Ophthalmology
Cite this
ICAM-1 expression in corneal epithelium of a patient with vernal keratoconjunctivitis : Case report. / Gill, Kuljit S.; Yannariello-Brown, Judith; Patel, Janak; Nakajima, Natsuki; Rajaraman, Srinivasan; Trocmé, Stefan D.
In: Cornea, Vol. 16, No. 1, 01.1997, p. 107-111.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - ICAM-1 expression in corneal epithelium of a patient with vernal keratoconjunctivitis
T2 - Case report
AU - Gill, Kuljit S.
AU - Yannariello-Brown, Judith
AU - Patel, Janak
AU - Nakajima, Natsuki
AU - Rajaraman, Srinivasan
AU - Trocmé, Stefan D.
PY - 1997/1
Y1 - 1997/1
N2 - Recent reports have demonstrated the expression of intercellular adhesion molecule-1 (ICAM-1; CD54) on the epithelium in various allergic diseases and inflammatory conditions, including the bronchial epithelium of patients with allergic asthma, conjunctival epithelium of allergic patients after allergen-specific challenge, and corneal epithelium of rejected corneal allografts. We investigated the presence of ICAM-1 expression on the corneal epithelium from a patient with vernal keratoconjunctivitis (VKC). Immunohistochemical staining of the diseased cornea demonstrated abundant ICAM-1 expression on the corneal epithelium. Immunoreactive ICAM-1 appeared to localize primarily to the cells of the basal and middle layers of the corneal epithelium. No staining was detected on the ocular surface epithelium. The normal, healthy cornea demonstrated no significant ICAM-1 expression on any of the epithelial layers, similar to that previously reported. To the best of our knowledge, this is the first report of ICAM-1 expression on the corneal epithelium from a patient with VKC.
AB - Recent reports have demonstrated the expression of intercellular adhesion molecule-1 (ICAM-1; CD54) on the epithelium in various allergic diseases and inflammatory conditions, including the bronchial epithelium of patients with allergic asthma, conjunctival epithelium of allergic patients after allergen-specific challenge, and corneal epithelium of rejected corneal allografts. We investigated the presence of ICAM-1 expression on the corneal epithelium from a patient with vernal keratoconjunctivitis (VKC). Immunohistochemical staining of the diseased cornea demonstrated abundant ICAM-1 expression on the corneal epithelium. Immunoreactive ICAM-1 appeared to localize primarily to the cells of the basal and middle layers of the corneal epithelium. No staining was detected on the ocular surface epithelium. The normal, healthy cornea demonstrated no significant ICAM-1 expression on any of the epithelial layers, similar to that previously reported. To the best of our knowledge, this is the first report of ICAM-1 expression on the corneal epithelium from a patient with VKC.
KW - Allergy
KW - CD54
KW - Corneal epithelium
KW - Inflammation
KW - Intercellular adhesion molecule-1
KW - Vernal keratoconjunctivitis
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UR - http://www.scopus.com/inward/citedby.url?scp=0031022939&partnerID=8YFLogxK
M3 - Article
C2 - 8985642
AN - SCOPUS:0031022939
VL - 16
SP - 107
EP - 111
JO - Cornea
JF - Cornea
SN - 0277-3740
IS - 1
ER -