ICircos: Visual analytics for translational bioinformatics

Suresh K. Bhavnani, Mamta Abbas, Vickie McMicken, Numan Oezguen, Jeffry Tupa

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Scopus citations

    Abstract

    Translational bioinformatics increasingly involves the discovery of associations between molecular and phenotype information, with the goal of transforming those discoveries into novel methods for diagnosis and treatment. To enable such complex analyses, researchers need approaches that provide the simultaneous representation and interactive analysis of patients, and their molecular and phenotype information. Because few existing visual analytical systems provide appropriate capabilities, we developed a prototypical visual analytical system called iCircos, which enables the simultaneous and interactive exploration of molecular and phenotype information. We discuss our overall method for developing the prototype by integrating user needs and design heuristics from visual analytics, with agile programming in HTML5 and SVG. A demonstration of the prototype to explore molecular and phenotype associations in two disease datasets suggests that iCircos has the potential to accelerate translational discoveries in complex disease datasets. We conclude by discussing insights about designing visual analytical systems for translational bioinformatics, and present our future plans for user testing and adding advanced interactivity to the prototype.

    Original languageEnglish (US)
    Title of host publicationIHI'12 - Proceedings of the 2nd ACM SIGHIT International Health Informatics Symposium
    Pages679-683
    Number of pages5
    DOIs
    StatePublished - Mar 8 2012
    Event2nd ACM SIGHIT International Health Informatics Symposium, IHI'12 - Miami, FL, United States
    Duration: Jan 28 2012Jan 30 2012

    Publication series

    NameIHI'12 - Proceedings of the 2nd ACM SIGHIT International Health Informatics Symposium

    Other

    Other2nd ACM SIGHIT International Health Informatics Symposium, IHI'12
    Country/TerritoryUnited States
    CityMiami, FL
    Period1/28/121/30/12

    Keywords

    • Circos
    • Translational bioinformatics
    • Visual analytics

    ASJC Scopus subject areas

    • Health Informatics
    • Health Information Management

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