ICOS is essential for the development of experimental autoimmune myasthenia gravis

Benjamin G. Scott, Huan Yang, Erdem Tüzün, Chen Dong, Richard A. Flavell, Premkumar Christadoss

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Lymphocyte costimulation via the inducible costimulatory molecule (ICOS) is required for effective humoral immunity development. Following immunization with Torpedo acetylcholine receptor (AChR), ICOS gene knockout (KO) mice were highly resistant to clinical experimental autoimmune myasthenia gravis (EAMG) development, had less serum AChR-specific immunoglobulins (Igs), and exhibited a diminutive germinal center (GC) reaction in secondary lymphoid tissues. Lymphocyte proliferation and both Th1 and Th2 differentiation in response to AChR and the AChR dominant α146-162 peptide were inhibited by the ICOS gene deficiency. ICOS-mediated lymphocyte costimulation is thus vital to the induction of T cell-mediated humoral immunity to AChR and the development of clinical EAMG.

Original languageEnglish (US)
Pages (from-to)16-25
Number of pages10
JournalJournal of Neuroimmunology
Volume153
Issue number1-2
DOIs
StatePublished - Aug 1 2004

Keywords

  • AChR
  • APC
  • Ab
  • Autoimmunity
  • B7RP-1
  • BTX
  • Costimulation
  • EAMG
  • Experimental autoimmune myasthenia gravis
  • ICOS
  • Ig
  • Myasthenia gravis
  • acetylcholine receptor
  • antibody
  • antigen presenting cell
  • experimental autoimmune myasthenia gravis
  • α-bungarotoxin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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  • Cite this

    Scott, B. G., Yang, H., Tüzün, E., Dong, C., Flavell, R. A., & Christadoss, P. (2004). ICOS is essential for the development of experimental autoimmune myasthenia gravis. Journal of Neuroimmunology, 153(1-2), 16-25. https://doi.org/10.1016/j.jneuroim.2004.04.019