ICOS is essential for the development of experimental autoimmune myasthenia gravis

Benjamin G. Scott; Huan Yang; Erdem Tüzün; Chen Dong; Richard A. Flavell; Premkumar Christadoss

doi:10.1016/j.jneuroim.2004.04.019

ICOS is essential for the development of experimental autoimmune myasthenia gravis

Benjamin G. Scott, Huan Yang, Erdem Tüzün, Chen Dong, Richard A. Flavell, Premkumar Christadoss

Microbiology And Immunology

Research output: Contribution to journal › Article

38 Scopus citations

Abstract

Lymphocyte costimulation via the inducible costimulatory molecule (ICOS) is required for effective humoral immunity development. Following immunization with Torpedo acetylcholine receptor (AChR), ICOS gene knockout (KO) mice were highly resistant to clinical experimental autoimmune myasthenia gravis (EAMG) development, had less serum AChR-specific immunoglobulins (Igs), and exhibited a diminutive germinal center (GC) reaction in secondary lymphoid tissues. Lymphocyte proliferation and both Th1 and Th2 differentiation in response to AChR and the AChR dominant α146-162 peptide were inhibited by the ICOS gene deficiency. ICOS-mediated lymphocyte costimulation is thus vital to the induction of T cell-mediated humoral immunity to AChR and the development of clinical EAMG.

Original language	English (US)
Pages (from-to)	16-25
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	153
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2004.04.019
State	Published - Aug 1 2004

Keywords

AChR
APC
Ab
Autoimmunity
B7RP-1
BTX
Costimulation
EAMG
Experimental autoimmune myasthenia gravis
ICOS
Ig
Myasthenia gravis
acetylcholine receptor
antibody
antigen presenting cell
experimental autoimmune myasthenia gravis
α-bungarotoxin

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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Scott, B. G., Yang, H., Tüzün, E., Dong, C., Flavell, R. A., & Christadoss, P. (2004). ICOS is essential for the development of experimental autoimmune myasthenia gravis. Journal of Neuroimmunology, 153(1-2), 16-25. https://doi.org/10.1016/j.jneuroim.2004.04.019

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title = "ICOS is essential for the development of experimental autoimmune myasthenia gravis",

abstract = "Lymphocyte costimulation via the inducible costimulatory molecule (ICOS) is required for effective humoral immunity development. Following immunization with Torpedo acetylcholine receptor (AChR), ICOS gene knockout (KO) mice were highly resistant to clinical experimental autoimmune myasthenia gravis (EAMG) development, had less serum AChR-specific immunoglobulins (Igs), and exhibited a diminutive germinal center (GC) reaction in secondary lymphoid tissues. Lymphocyte proliferation and both Th1 and Th2 differentiation in response to AChR and the AChR dominant α146-162 peptide were inhibited by the ICOS gene deficiency. ICOS-mediated lymphocyte costimulation is thus vital to the induction of T cell-mediated humoral immunity to AChR and the development of clinical EAMG.",

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author = "Scott, {Benjamin G.} and Huan Yang and Erdem T{\"u}z{\"u}n and Chen Dong and Flavell, {Richard A.} and Premkumar Christadoss",

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AU - Scott, Benjamin G.

AU - Yang, Huan

AU - Tüzün, Erdem

AU - Dong, Chen

AU - Flavell, Richard A.

AU - Christadoss, Premkumar

PY - 2004/8/1

Y1 - 2004/8/1

N2 - Lymphocyte costimulation via the inducible costimulatory molecule (ICOS) is required for effective humoral immunity development. Following immunization with Torpedo acetylcholine receptor (AChR), ICOS gene knockout (KO) mice were highly resistant to clinical experimental autoimmune myasthenia gravis (EAMG) development, had less serum AChR-specific immunoglobulins (Igs), and exhibited a diminutive germinal center (GC) reaction in secondary lymphoid tissues. Lymphocyte proliferation and both Th1 and Th2 differentiation in response to AChR and the AChR dominant α146-162 peptide were inhibited by the ICOS gene deficiency. ICOS-mediated lymphocyte costimulation is thus vital to the induction of T cell-mediated humoral immunity to AChR and the development of clinical EAMG.

AB - Lymphocyte costimulation via the inducible costimulatory molecule (ICOS) is required for effective humoral immunity development. Following immunization with Torpedo acetylcholine receptor (AChR), ICOS gene knockout (KO) mice were highly resistant to clinical experimental autoimmune myasthenia gravis (EAMG) development, had less serum AChR-specific immunoglobulins (Igs), and exhibited a diminutive germinal center (GC) reaction in secondary lymphoid tissues. Lymphocyte proliferation and both Th1 and Th2 differentiation in response to AChR and the AChR dominant α146-162 peptide were inhibited by the ICOS gene deficiency. ICOS-mediated lymphocyte costimulation is thus vital to the induction of T cell-mediated humoral immunity to AChR and the development of clinical EAMG.

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KW - experimental autoimmune myasthenia gravis

KW - α-bungarotoxin

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