ICOS is essential for the development of experimental autoimmune myasthenia gravis

Benjamin G. Scott, Huan Yang, Erdem Tüzün, Chen Dong, Richard A. Flavell, Premkumar Christadoss

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Lymphocyte costimulation via the inducible costimulatory molecule (ICOS) is required for effective humoral immunity development. Following immunization with Torpedo acetylcholine receptor (AChR), ICOS gene knockout (KO) mice were highly resistant to clinical experimental autoimmune myasthenia gravis (EAMG) development, had less serum AChR-specific immunoglobulins (Igs), and exhibited a diminutive germinal center (GC) reaction in secondary lymphoid tissues. Lymphocyte proliferation and both Th1 and Th2 differentiation in response to AChR and the AChR dominant α146-162 peptide were inhibited by the ICOS gene deficiency. ICOS-mediated lymphocyte costimulation is thus vital to the induction of T cell-mediated humoral immunity to AChR and the development of clinical EAMG.

Original languageEnglish (US)
Pages (from-to)16-25
Number of pages10
JournalJournal of Neuroimmunology
Volume153
Issue number1-2
DOIs
StatePublished - Aug 2004

Fingerprint

Autoimmune Experimental Myasthenia Gravis
Cholinergic Receptors
Lymphocytes
Humoral Immunity
Torpedo
Gene Knockout Techniques
Germinal Center
Lymphoid Tissue
Knockout Mice
Cellular Immunity
Immunoglobulins
Immunization
T-Lymphocytes
Peptides
Serum
Genes

Keywords

  • α-bungarotoxin
  • Ab
  • acetylcholine receptor
  • AChR
  • antibody
  • antigen presenting cell
  • APC
  • Autoimmunity
  • B7RP-1
  • BTX
  • Costimulation
  • EAMG
  • Experimental autoimmune myasthenia gravis
  • experimental autoimmune myasthenia gravis
  • ICOS
  • Ig
  • Myasthenia gravis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Scott, B. G., Yang, H., Tüzün, E., Dong, C., Flavell, R. A., & Christadoss, P. (2004). ICOS is essential for the development of experimental autoimmune myasthenia gravis. Journal of Neuroimmunology, 153(1-2), 16-25. https://doi.org/10.1016/j.jneuroim.2004.04.019

ICOS is essential for the development of experimental autoimmune myasthenia gravis. / Scott, Benjamin G.; Yang, Huan; Tüzün, Erdem; Dong, Chen; Flavell, Richard A.; Christadoss, Premkumar.

In: Journal of Neuroimmunology, Vol. 153, No. 1-2, 08.2004, p. 16-25.

Research output: Contribution to journalArticle

Scott, BG, Yang, H, Tüzün, E, Dong, C, Flavell, RA & Christadoss, P 2004, 'ICOS is essential for the development of experimental autoimmune myasthenia gravis', Journal of Neuroimmunology, vol. 153, no. 1-2, pp. 16-25. https://doi.org/10.1016/j.jneuroim.2004.04.019
Scott, Benjamin G. ; Yang, Huan ; Tüzün, Erdem ; Dong, Chen ; Flavell, Richard A. ; Christadoss, Premkumar. / ICOS is essential for the development of experimental autoimmune myasthenia gravis. In: Journal of Neuroimmunology. 2004 ; Vol. 153, No. 1-2. pp. 16-25.
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