ICTV Virus Taxonomy Profile: Filoviridae 2024

Nadine Biedenkopf; Alexander Bukreyev; Kartik Chandran; Nicholas Di Paola; Pierre B.H. Formenty; Anthony Griffiths; Adam J. Hume; Elke Mühlberger; Sergey V. Netesov; Gustavo Palacios; Janusz T. Pawęska; Sophie Smither; Ayato Takada; Victoria Wahl; Jens H. Kuhn

doi:10.1099/jgv.0.001955

ICTV Virus Taxonomy Profile: Filoviridae 2024

Nadine Biedenkopf, Alexander Bukreyev, Kartik Chandran, Nicholas Di Paola, Pierre B.H. Formenty, Anthony Griffiths, Adam J. Hume, Elke Mühlberger, Sergey V. Netesov, Gustavo Palacios, Janusz T. Pawęska, Sophie Smither, Ayato Takada, Victoria Wahl, Jens H. Kuhn

Pathology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Filoviridae is a family of negative-sense RNA viruses with genomes of about 13.1–20.9 kb that infect fish, mammals and reptiles. The filovirid genome is a linear, non-segmented RNA with five canonical open reading frames (ORFs) that encode a nucleoprotein (NP), a polymerase cofactor (VP35), a glycoprotein (GP_1,2), a transcriptional activator (VP30) and a large protein (L) containing an RNA-directed RNA polymerase (RdRP) domain. All filovirid genomes encode additional proteins that vary among genera. Several filovirids (e.g., Ebola virus, Marburg virus) are pathogenic for humans and highly virulent. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family Filoviridae, which is available at www.ictv.global/report/filoviridae.

Original language	English (US)
Journal	Journal of General Virology
Volume	105
Issue number	2
DOIs	https://doi.org/10.1099/jgv.0.001955
State	Published - Feb 2024

Keywords

Ebola
Filoviridae
ICTV Report
Marburg virus
filovirid
filovirus
orthoebolavirus
orthomarburgvirus
taxonomy

ASJC Scopus subject areas

Virology

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title = "ICTV Virus Taxonomy Profile: Filoviridae 2024",

abstract = "Filoviridae is a family of negative-sense RNA viruses with genomes of about 13.1–20.9 kb that infect fish, mammals and reptiles. The filovirid genome is a linear, non-segmented RNA with five canonical open reading frames (ORFs) that encode a nucleoprotein (NP), a polymerase cofactor (VP35), a glycoprotein (GP1,2), a transcriptional activator (VP30) and a large protein (L) containing an RNA-directed RNA polymerase (RdRP) domain. All filovirid genomes encode additional proteins that vary among genera. Several filovirids (e.g., Ebola virus, Marburg virus) are pathogenic for humans and highly virulent. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family Filoviridae, which is available at www.ictv.global/report/filoviridae.",

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AU - Biedenkopf, Nadine

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AU - Chandran, Kartik

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AU - Formenty, Pierre B.H.

AU - Griffiths, Anthony

AU - Hume, Adam J.

AU - Mühlberger, Elke

AU - Netesov, Sergey V.

AU - Palacios, Gustavo

AU - Pawęska, Janusz T.

AU - Smither, Sophie

AU - Takada, Ayato

AU - Wahl, Victoria

AU - Kuhn, Jens H.

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AB - Filoviridae is a family of negative-sense RNA viruses with genomes of about 13.1–20.9 kb that infect fish, mammals and reptiles. The filovirid genome is a linear, non-segmented RNA with five canonical open reading frames (ORFs) that encode a nucleoprotein (NP), a polymerase cofactor (VP35), a glycoprotein (GP1,2), a transcriptional activator (VP30) and a large protein (L) containing an RNA-directed RNA polymerase (RdRP) domain. All filovirid genomes encode additional proteins that vary among genera. Several filovirids (e.g., Ebola virus, Marburg virus) are pathogenic for humans and highly virulent. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family Filoviridae, which is available at www.ictv.global/report/filoviridae.

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ICTV Virus Taxonomy Profile: Filoviridae 2024

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Keywords

ASJC Scopus subject areas

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