Identification and analysis of extended strands and β-sheets in globular proteins

K. V. Soman, C. Ramakrishnan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A method to identify β-sheets in globular proteins from extended strands, using only α-carbon positions, has been developed. The strands that form β-sheets are picked up by means of simple distance criteria. The method has been tested by applying it to three proteins with accurately known secondary structures. It has also been applied to ten other proteins wherein only α-carbon coordinates are available, and the list of β-sheets obtained. The following points are worth noting: (i) The sheets identified by the algorithm are found to agree satisfactorily with the reported ones based on backbone hydrogen bonding, wherever this information is available. (ii) β-Strands that do not form parts of any sheet are a common feature of protein structures. (iii) Such isolated β-strands tend to be short. (iv) The conformation corresponding to the preferred right-handed twist of the sheet is overwhelmingly observed in both the sheet-forming and isolated β-strands.

Original languageEnglish (US)
Pages (from-to)89-96
Number of pages8
JournalInternational Journal of Biological Macromolecules
Volume8
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Proteins
Carbon
Hydrogen Bonding
Conformations
Hydrogen bonds

Keywords

  • extended strands
  • Proteins
  • secondary structure
  • β-sheets
  • β-strands

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Identification and analysis of extended strands and β-sheets in globular proteins. / Soman, K. V.; Ramakrishnan, C.

In: International Journal of Biological Macromolecules, Vol. 8, No. 2, 1986, p. 89-96.

Research output: Contribution to journalArticle

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