Identification and antibiotic susceptibility of bacterial isolates from burned patients

John F. Hansbrough, Wendy B. Carroll, Ramon Zapata Sirvent, Barth R. Reller, John A. Boswick

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We retrieved bacterial blood isolates from 397 adult burned patients admitted over a 7-year period. Sixty-two patients (15·6 per cent) developed true-positive bacterial blood cultures (judged non-contaminants), and of these 30 (48·4 per cent) expired. Pseudomonas aeruginosa (24 isolates), Staphylococcus aureus (19) and Klebsiella pneumoniae (19) were the most frequent isolates. In vitro susceptibilities of 149 isolates were determined to 12 antibiotics (gentamicin, amikacin, ticarcillin, piperacillin, mezlocillin, azlocillin, cefazolin, cefotaxime, ceftazidime, cefoperazone, thienamycin and ticarcillin-clavulinic acid) using agar diffusion assay. Thienamycin proved the most active agent (97 per cent of isolates susceptible). Cefoperazone was the most active cephalosporin (95 per cent susceptible). Twenty-eight organisms demonstrated multiple drug resistance; patients with such organisms had a 71 per cent mortality. Thienamycin was the most active agent against such isolates ( 27 28 susceptible). Susceptibilities of all 149 isolates to combinations of antibiotics were calculated, assuming no synergism or antagonism; some combinations of third-generation cephalosporins with the newer penicillins may prove to be as effective as combinations including aminoglycosides.

Original languageEnglish (US)
Pages (from-to)393-403
Number of pages11
JournalBurns
Volume11
Issue number6
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

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Ticarcillin
Cefoperazone
Cephalosporins
Anti-Bacterial Agents
Azlocillin
Mezlocillin
Staphylococcal Pneumonia
Cefazolin
Piperacillin
Ceftazidime
Amikacin
Cefotaxime
Klebsiella pneumoniae
Multiple Drug Resistance
Aminoglycosides
Gentamicins
Penicillins
Pseudomonas aeruginosa
Agar
Acids

ASJC Scopus subject areas

  • Emergency Medicine
  • Surgery

Cite this

Identification and antibiotic susceptibility of bacterial isolates from burned patients. / Hansbrough, John F.; Carroll, Wendy B.; Zapata Sirvent, Ramon; Reller, Barth R.; Boswick, John A.

In: Burns, Vol. 11, No. 6, 01.01.1985, p. 393-403.

Research output: Contribution to journalArticle

Hansbrough, John F. ; Carroll, Wendy B. ; Zapata Sirvent, Ramon ; Reller, Barth R. ; Boswick, John A. / Identification and antibiotic susceptibility of bacterial isolates from burned patients. In: Burns. 1985 ; Vol. 11, No. 6. pp. 393-403.
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