Identification and Characterization of the Direct Interaction between Methotrexate (MTX) and High-Mobility Group Box 1 (HMGB1) Protein

Medicine & Life Sciences

• Anti-Inflammatory Agents 14%
• Autoimmune Diseases 4%
• Bacteriophage T7 21%
• Binding Sites 3%
• Carrier Proteins 8%
• DNA 2%
• Drug Therapy 2%
• Electrophoretic Mobility Shift Assay 5%
• HMG-Box Domains 9%
• HMGB1 Protein 100%
• Macrophages 3%
• Methotrexate 72%
• Neoplasms 3%
• RAW 264.7 Cells 6%
• Rheumatoid Arthritis 4%
• Surface Plasmon Resonance 6%
• Tetrahydrofolate Dehydrogenase 6%

Agriculture & Biology

• anti-inflammatory activity 21%
• assays 2%
• autoimmune diseases 6%
• binding proteins 8%
• binding sites 4%
• cells 1%
• chemical derivatives 3%
• dihydrofolate reductase 6%
• DNA 2%
• drug therapy 4%
• macrophages 4%
• mechanism of action 8%
• methodology 1%
• methotrexate 97%
• mice 2%
• neoplasms 7%
• phages 13%
• proteins 25%
• rheumatoid arthritis 6%
• screening 3%
• surface plasmon resonance 7%

Chemical Compounds

• Antiinflammatory 20%
• Binding Site 3%
• Dihydrofolates 6%
• Kd 8%
• Methotrexate 93%
• Protein 31%
• Surface Plasmon Resonance 5%