Identification and functional analysis of an immunoreactive DsbA-like thio-disulfide oxidoreductase of Ehrlichia spp.

Jere W. McBride; Lucy M. Ndip; Vsevolod L. Popov; David H. Walker

doi:10.1128/IAI.70.5.2700-2703.2002

Identification and functional analysis of an immunoreactive DsbA-like thio-disulfide oxidoreductase of Ehrlichia spp.

Jere W. McBride, Lucy M. Ndip, Vsevolod L. Popov, David H. Walker

Pathology

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Novel homologous DsbA-like disulfide bond formation (Dsb) proteins of Ehrlichia chaffeensis and Ehrlichia canis were identified which restored DsbA activity in complemented Escherichia coli dsbA mutants. Recombinant Ehrlichia Dsb (eDsb) proteins were recognized by sera from E. canis-infected dogs but not from E. chaffeensis-infected patients. The eDsb proteins were observed primarily in the periplasm of E. chaffeensis and E. canis.

Original language	English (US)
Pages (from-to)	2700-2703
Number of pages	4
Journal	Infection and immunity
Volume	70
Issue number	5
DOIs	https://doi.org/10.1128/IAI.70.5.2700-2703.2002
State	Published - 2002

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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T1 - Identification and functional analysis of an immunoreactive DsbA-like thio-disulfide oxidoreductase of Ehrlichia spp.

AU - McBride, Jere W.

AU - Ndip, Lucy M.

AU - Popov, Vsevolod L.

AU - Walker, David H.

PY - 2002

Y1 - 2002

N2 - Novel homologous DsbA-like disulfide bond formation (Dsb) proteins of Ehrlichia chaffeensis and Ehrlichia canis were identified which restored DsbA activity in complemented Escherichia coli dsbA mutants. Recombinant Ehrlichia Dsb (eDsb) proteins were recognized by sera from E. canis-infected dogs but not from E. chaffeensis-infected patients. The eDsb proteins were observed primarily in the periplasm of E. chaffeensis and E. canis.

AB - Novel homologous DsbA-like disulfide bond formation (Dsb) proteins of Ehrlichia chaffeensis and Ehrlichia canis were identified which restored DsbA activity in complemented Escherichia coli dsbA mutants. Recombinant Ehrlichia Dsb (eDsb) proteins were recognized by sera from E. canis-infected dogs but not from E. chaffeensis-infected patients. The eDsb proteins were observed primarily in the periplasm of E. chaffeensis and E. canis.

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AN - SCOPUS:0036117915

SN - 0019-9567

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JO - Infection and immunity

JF - Infection and immunity

IS - 5

ER -

Identification and functional analysis of an immunoreactive DsbA-like thio-disulfide oxidoreductase of Ehrlichia spp.

Abstract

ASJC Scopus subject areas

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