Identification of a 1.4-kb-Long Sequence Located in the nsp12 and nsp13 Coding Regions of SARS-CoV-2 Genomic RNA That Mediates Efficient Viral RNA Packaging

Keyphrases

• Pregenomic RNA (pgRNA) 100%
• Coding Region 100%
• Viral Packaging 100%
• Long Sequence 100%
• Nsp13 100%
• Severe Acute Respiratory syndrome-CoV-2 100%
• Nsp12 100%
• Virus-like Particles 30%
• RNA Packaging 30%
• Coronavirus 15%
• Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 10%
• Mouse Hepatitis Virus 10%
• Replication Cycle 10%
• Minigenome 10%
• Sarbecovirus 10%
• Targeted Therapeutics 5%
• Viral Genome 5%
• Cell Culture 5%
• Structural Features 5%
• Serial Passage 5%
• RNA Element 5%
• Antiviral Drugs 5%
• Rational Design 5%
• Replication-competent 5%
• Biosafety Level 3 5%
• Defective RNA 5%
• Long RNAs 5%
• Viral Genomic RNA 5%
• Viral RNA Genome 5%
• Logistical Challenges 5%
• Packaging Signal 5%
• Betacoronavirus 5%
• Nsp15 5%

Biochemistry, Genetics and Molecular Biology

• RNA 100%
• Coding Region 100%
• Genomics 100%
• Virus Particle 25%
• Murine Hepatitis Virus 8%
• SARS Coronavirus 8%
• Cell Culture 4%
• Betacoronavirus 4%

Immunology and Microbiology

• Severe Acute Respiratory Syndrome 100%
• Ribonucleic Acid 100%
• Virus Particle 26%
• Coronavirus 13%
• Replication 13%
• Murine Hepatitis Virus 8%
• SARS Coronavirus 8%
• Cell Culture 4%
• Defective Interfering RNA 4%
• Betacoronavirus 4%