Identification of autophagy-inhibiting factors of mycobacterium tuberculosis by high-throughput loss-of-function screening

Keyphrases

• Autophagy 100%
• Mycobacterium Tuberculosis (M. tb) 100%
• High-throughput 100%
• Loss Function 100%
• Inhibiting Factors 100%
• Throughput Loss 100%
• Host Cell 33%
• Innate Immunity 16%
• Survival Rate 16%
• Infected Cells 16%
• Virulence Factors 16%
• Latent Infection 16%
• Intracellular Bacteria 16%
• Differential Expression 16%
• Interleukin-1β 16%
• Tumor Necrosis Factor-α 16%
• Host Cell Response 16%
• Mammalian Target of Rapamycin (mTOR) 16%
• Microbes 16%
• Adaptive Immunity 16%
• Protein Family 16%
• Infected Macrophages 16%
• Tuberculosis 16%
• Stress Conditions 16%
• Phagocytes 16%
• Bacterial Clearance 16%
• Intracellular Survival 16%
• Bacterial Replication 16%
• One-component 16%
• Evade 16%
• Mycobacterium 16%
• Targeted Deletion 16%
• Multiple Outcomes 16%
• Mycobacterium Smegmatis 16%
• Transposon mutant Library 16%
• Autophagy Inhibition 16%
• Bacterial Persistence 16%

Immunology and Microbiology

• Autophagy 100%
• Mycobacterium Tuberculosis 100%
• Host Cell 42%
• Innate Immune System 14%
• Survival Rate 14%
• Wild Type 14%
• Macrophage 14%
• Virulence Factor 14%
• Adaptive Immune System 14%
• Intracellular Bacterium 14%
• Interleukin 1 14%
• Protein Family 14%
• Tumor Necrosis Factor Alpha 14%
• Phagocyte 14%
• Bacterial Clearance 14%
• Transposon 14%
• Mycobacteria 14%
• Sirolimus 14%
• Mycobacterium Smegmatis 14%
• Microorganism 14%