Identification of Biofilm Inhibitors by Screening Combinatorial Libraries of Metal Oxide Thin Films

Michal M. Dykas, Stuti K. Desai, Abhijeet Patra, Mallikarjuna Rao Motapothula, Kingshuk Poddar, Linda Kenney, T. Venkatesan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

With the rise in nosocomial infections worldwide, research on materials with an intrinsic ability to inhibit biofilm formation has been generating a great deal of interest. In the present work, we describe how thin film material libraries generated by pulsed laser deposition can be used for simultaneously screening several novel metal oxide mixtures that inhibit biofilm formation in a common human pathogen, Salmonella enterica serovar Typhimurium. We discovered that in a material library constructed using two metal oxides, the net effect on biofilm formation can be modeled as an addition of the activities of the individual oxides weighted to their relative composition at that particular point on the library. In contrast, for similar material libraries constructed using three metal oxides, there was a nonlinear relation between the amount of dominant metal oxide and the formation of Salmonella biofilms. This nonlinearity resulted in several useful metal oxide combinations that were not expected from the weighted average predictions. Our novel application will lead to the discovery of additional alternatives for creating antimicrobial surfaces.

Original languageEnglish (US)
Pages (from-to)12510-12517
Number of pages8
JournalACS Applied Materials and Interfaces
Volume10
Issue number15
DOIs
StatePublished - Apr 18 2018
Externally publishedYes

Fingerprint

Biofilms
Corrosion inhibitors
Oxides
Oxide films
Screening
Metals
Thin films
Salmonella
Pathogens
Pulsed laser deposition
Chemical analysis

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Identification of Biofilm Inhibitors by Screening Combinatorial Libraries of Metal Oxide Thin Films. / Dykas, Michal M.; Desai, Stuti K.; Patra, Abhijeet; Motapothula, Mallikarjuna Rao; Poddar, Kingshuk; Kenney, Linda; Venkatesan, T.

In: ACS Applied Materials and Interfaces, Vol. 10, No. 15, 18.04.2018, p. 12510-12517.

Research output: Contribution to journalArticle

Dykas, Michal M. ; Desai, Stuti K. ; Patra, Abhijeet ; Motapothula, Mallikarjuna Rao ; Poddar, Kingshuk ; Kenney, Linda ; Venkatesan, T. / Identification of Biofilm Inhibitors by Screening Combinatorial Libraries of Metal Oxide Thin Films. In: ACS Applied Materials and Interfaces. 2018 ; Vol. 10, No. 15. pp. 12510-12517.
@article{fdcf7e4ad8594141b3c160eddfb24140,
title = "Identification of Biofilm Inhibitors by Screening Combinatorial Libraries of Metal Oxide Thin Films",
abstract = "With the rise in nosocomial infections worldwide, research on materials with an intrinsic ability to inhibit biofilm formation has been generating a great deal of interest. In the present work, we describe how thin film material libraries generated by pulsed laser deposition can be used for simultaneously screening several novel metal oxide mixtures that inhibit biofilm formation in a common human pathogen, Salmonella enterica serovar Typhimurium. We discovered that in a material library constructed using two metal oxides, the net effect on biofilm formation can be modeled as an addition of the activities of the individual oxides weighted to their relative composition at that particular point on the library. In contrast, for similar material libraries constructed using three metal oxides, there was a nonlinear relation between the amount of dominant metal oxide and the formation of Salmonella biofilms. This nonlinearity resulted in several useful metal oxide combinations that were not expected from the weighted average predictions. Our novel application will lead to the discovery of additional alternatives for creating antimicrobial surfaces.",
author = "Dykas, {Michal M.} and Desai, {Stuti K.} and Abhijeet Patra and Motapothula, {Mallikarjuna Rao} and Kingshuk Poddar and Linda Kenney and T. Venkatesan",
year = "2018",
month = "4",
day = "18",
doi = "10.1021/acsami.8b02246",
language = "English (US)",
volume = "10",
pages = "12510--12517",
journal = "ACS applied materials & interfaces",
issn = "1944-8244",
publisher = "American Chemical Society",
number = "15",

}

TY - JOUR

T1 - Identification of Biofilm Inhibitors by Screening Combinatorial Libraries of Metal Oxide Thin Films

AU - Dykas, Michal M.

AU - Desai, Stuti K.

AU - Patra, Abhijeet

AU - Motapothula, Mallikarjuna Rao

AU - Poddar, Kingshuk

AU - Kenney, Linda

AU - Venkatesan, T.

PY - 2018/4/18

Y1 - 2018/4/18

N2 - With the rise in nosocomial infections worldwide, research on materials with an intrinsic ability to inhibit biofilm formation has been generating a great deal of interest. In the present work, we describe how thin film material libraries generated by pulsed laser deposition can be used for simultaneously screening several novel metal oxide mixtures that inhibit biofilm formation in a common human pathogen, Salmonella enterica serovar Typhimurium. We discovered that in a material library constructed using two metal oxides, the net effect on biofilm formation can be modeled as an addition of the activities of the individual oxides weighted to their relative composition at that particular point on the library. In contrast, for similar material libraries constructed using three metal oxides, there was a nonlinear relation between the amount of dominant metal oxide and the formation of Salmonella biofilms. This nonlinearity resulted in several useful metal oxide combinations that were not expected from the weighted average predictions. Our novel application will lead to the discovery of additional alternatives for creating antimicrobial surfaces.

AB - With the rise in nosocomial infections worldwide, research on materials with an intrinsic ability to inhibit biofilm formation has been generating a great deal of interest. In the present work, we describe how thin film material libraries generated by pulsed laser deposition can be used for simultaneously screening several novel metal oxide mixtures that inhibit biofilm formation in a common human pathogen, Salmonella enterica serovar Typhimurium. We discovered that in a material library constructed using two metal oxides, the net effect on biofilm formation can be modeled as an addition of the activities of the individual oxides weighted to their relative composition at that particular point on the library. In contrast, for similar material libraries constructed using three metal oxides, there was a nonlinear relation between the amount of dominant metal oxide and the formation of Salmonella biofilms. This nonlinearity resulted in several useful metal oxide combinations that were not expected from the weighted average predictions. Our novel application will lead to the discovery of additional alternatives for creating antimicrobial surfaces.

UR - http://www.scopus.com/inward/record.url?scp=85045648345&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045648345&partnerID=8YFLogxK

U2 - 10.1021/acsami.8b02246

DO - 10.1021/acsami.8b02246

M3 - Article

VL - 10

SP - 12510

EP - 12517

JO - ACS applied materials & interfaces

JF - ACS applied materials & interfaces

SN - 1944-8244

IS - 15

ER -