Identification of Biofilm Inhibitors by Screening Combinatorial Libraries of Metal Oxide Thin Films

Michal M. Dykas, Stuti K. Desai, Abhijeet Patra, Mallikarjuna Rao Motapothula, Kingshuk Poddar, Linda J. Kenney, T. Venkatesan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


With the rise in nosocomial infections worldwide, research on materials with an intrinsic ability to inhibit biofilm formation has been generating a great deal of interest. In the present work, we describe how thin film material libraries generated by pulsed laser deposition can be used for simultaneously screening several novel metal oxide mixtures that inhibit biofilm formation in a common human pathogen, Salmonella enterica serovar Typhimurium. We discovered that in a material library constructed using two metal oxides, the net effect on biofilm formation can be modeled as an addition of the activities of the individual oxides weighted to their relative composition at that particular point on the library. In contrast, for similar material libraries constructed using three metal oxides, there was a nonlinear relation between the amount of dominant metal oxide and the formation of Salmonella biofilms. This nonlinearity resulted in several useful metal oxide combinations that were not expected from the weighted average predictions. Our novel application will lead to the discovery of additional alternatives for creating antimicrobial surfaces.

Original languageEnglish (US)
Pages (from-to)12510-12517
Number of pages8
JournalACS Applied Materials and Interfaces
Issue number15
StatePublished - Apr 18 2018
Externally publishedYes

ASJC Scopus subject areas

  • General Materials Science


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