Abstract
With the rise in nosocomial infections worldwide, research on materials with an intrinsic ability to inhibit biofilm formation has been generating a great deal of interest. In the present work, we describe how thin film material libraries generated by pulsed laser deposition can be used for simultaneously screening several novel metal oxide mixtures that inhibit biofilm formation in a common human pathogen, Salmonella enterica serovar Typhimurium. We discovered that in a material library constructed using two metal oxides, the net effect on biofilm formation can be modeled as an addition of the activities of the individual oxides weighted to their relative composition at that particular point on the library. In contrast, for similar material libraries constructed using three metal oxides, there was a nonlinear relation between the amount of dominant metal oxide and the formation of Salmonella biofilms. This nonlinearity resulted in several useful metal oxide combinations that were not expected from the weighted average predictions. Our novel application will lead to the discovery of additional alternatives for creating antimicrobial surfaces.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 12510-12517 |
| Number of pages | 8 |
| Journal | ACS Applied Materials and Interfaces |
| Volume | 10 |
| Issue number | 15 |
| DOIs | |
| State | Published - Apr 18 2018 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Materials Science(all)
Cite this
Identification of Biofilm Inhibitors by Screening Combinatorial Libraries of Metal Oxide Thin Films. / Dykas, Michal M.; Desai, Stuti K.; Patra, Abhijeet; Motapothula, Mallikarjuna Rao; Poddar, Kingshuk; Kenney, Linda; Venkatesan, T.
In: ACS Applied Materials and Interfaces, Vol. 10, No. 15, 18.04.2018, p. 12510-12517.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of Biofilm Inhibitors by Screening Combinatorial Libraries of Metal Oxide Thin Films
AU - Dykas, Michal M.
AU - Desai, Stuti K.
AU - Patra, Abhijeet
AU - Motapothula, Mallikarjuna Rao
AU - Poddar, Kingshuk
AU - Kenney, Linda
AU - Venkatesan, T.
PY - 2018/4/18
Y1 - 2018/4/18
N2 - With the rise in nosocomial infections worldwide, research on materials with an intrinsic ability to inhibit biofilm formation has been generating a great deal of interest. In the present work, we describe how thin film material libraries generated by pulsed laser deposition can be used for simultaneously screening several novel metal oxide mixtures that inhibit biofilm formation in a common human pathogen, Salmonella enterica serovar Typhimurium. We discovered that in a material library constructed using two metal oxides, the net effect on biofilm formation can be modeled as an addition of the activities of the individual oxides weighted to their relative composition at that particular point on the library. In contrast, for similar material libraries constructed using three metal oxides, there was a nonlinear relation between the amount of dominant metal oxide and the formation of Salmonella biofilms. This nonlinearity resulted in several useful metal oxide combinations that were not expected from the weighted average predictions. Our novel application will lead to the discovery of additional alternatives for creating antimicrobial surfaces.
AB - With the rise in nosocomial infections worldwide, research on materials with an intrinsic ability to inhibit biofilm formation has been generating a great deal of interest. In the present work, we describe how thin film material libraries generated by pulsed laser deposition can be used for simultaneously screening several novel metal oxide mixtures that inhibit biofilm formation in a common human pathogen, Salmonella enterica serovar Typhimurium. We discovered that in a material library constructed using two metal oxides, the net effect on biofilm formation can be modeled as an addition of the activities of the individual oxides weighted to their relative composition at that particular point on the library. In contrast, for similar material libraries constructed using three metal oxides, there was a nonlinear relation between the amount of dominant metal oxide and the formation of Salmonella biofilms. This nonlinearity resulted in several useful metal oxide combinations that were not expected from the weighted average predictions. Our novel application will lead to the discovery of additional alternatives for creating antimicrobial surfaces.
UR - http://www.scopus.com/inward/record.url?scp=85045648345&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045648345&partnerID=8YFLogxK
U2 - 10.1021/acsami.8b02246
DO - 10.1021/acsami.8b02246
M3 - Article
C2 - 29553712
AN - SCOPUS:85045648345
VL - 10
SP - 12510
EP - 12517
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
SN - 1944-8244
IS - 15
ER -