Identification of dengue fever cases in Houston, Texas, with evidence of autochthonous transmission between 2003 and 2005

Kristy O. Murray, Liliana F. Rodriguez, Emily Herrington, Vineetkumar Kharat, Nikos Vasilakis, Christopher Walker, Cynthia Turner, Salma Khuwaja, Raouf Arafat, Scott Weaver, Diana Martinez, Cindy Kilborn, Rudy Bueno, Martin Reyna

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Houston, Texas, maintains an environment conducive to dengue virus (DENV) emergence; however, surveillance is passive and diagnostic testing is not readily available. To determine if DENV is present in the area, we tested 3768 clinical specimens (2138 cerebrospinal fluid [CSF] and 1630 serum) collected from patients with suspected mosquito-borne viral disease between 2003 and 2005. We identified 47 immunoglobulin M (IgM)-positive dengue cases, including two cases that were positive for viral RNA in serum for dengue serotype 2. The majority of cases did not report any history of travel outside the Houston area prior to symptom onset. The epidemic curve suggests an outbreak occurred in 2003 with continued low-level transmission in 2004 and 2005. Chart abstractions were completed for 42 of the 47 cases; 57% were diagnosed with meningitis and/or encephalitis, and 43% met the case definition for dengue fever. Two of the 47 cases were fatal, including one with illness compatible with dengue shock syndrome. Our results support local transmission of DENV during the study period. These findings heighten the need for dengue surveillance in the southern United States.

Original languageEnglish (US)
Pages (from-to)835-845
Number of pages11
JournalVector-Borne and Zoonotic Diseases
Volume13
Issue number12
DOIs
StatePublished - Dec 1 2013

Fingerprint

Infectious Disease Transmission
Dengue
Dengue Virus
Severe Dengue
Viral RNA
Virus Diseases
Encephalitis
Culicidae
Serum
Meningitis
Disease Outbreaks
Immunoglobulin M
Cerebrospinal Fluid

Keywords

  • Dengue virus
  • IgM enzyme-linked immunosorbent assay
  • Meningitis
  • RT-PCR
  • Surveillance
  • West Nile virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology
  • Virology

Cite this

Identification of dengue fever cases in Houston, Texas, with evidence of autochthonous transmission between 2003 and 2005. / Murray, Kristy O.; Rodriguez, Liliana F.; Herrington, Emily; Kharat, Vineetkumar; Vasilakis, Nikos; Walker, Christopher; Turner, Cynthia; Khuwaja, Salma; Arafat, Raouf; Weaver, Scott; Martinez, Diana; Kilborn, Cindy; Bueno, Rudy; Reyna, Martin.

In: Vector-Borne and Zoonotic Diseases, Vol. 13, No. 12, 01.12.2013, p. 835-845.

Research output: Contribution to journalArticle

Murray, KO, Rodriguez, LF, Herrington, E, Kharat, V, Vasilakis, N, Walker, C, Turner, C, Khuwaja, S, Arafat, R, Weaver, S, Martinez, D, Kilborn, C, Bueno, R & Reyna, M 2013, 'Identification of dengue fever cases in Houston, Texas, with evidence of autochthonous transmission between 2003 and 2005', Vector-Borne and Zoonotic Diseases, vol. 13, no. 12, pp. 835-845. https://doi.org/10.1089/vbz.2013.1413
Murray, Kristy O. ; Rodriguez, Liliana F. ; Herrington, Emily ; Kharat, Vineetkumar ; Vasilakis, Nikos ; Walker, Christopher ; Turner, Cynthia ; Khuwaja, Salma ; Arafat, Raouf ; Weaver, Scott ; Martinez, Diana ; Kilborn, Cindy ; Bueno, Rudy ; Reyna, Martin. / Identification of dengue fever cases in Houston, Texas, with evidence of autochthonous transmission between 2003 and 2005. In: Vector-Borne and Zoonotic Diseases. 2013 ; Vol. 13, No. 12. pp. 835-845.
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